New hope for brain infection: experimental combo tackles tuberculous meningitis

NCT ID NCT07227779

Recruiting now Disease control Sponsor: David Boulware Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 6 times

Summary

This study tests a new combination of medicines (BPaLMZ) against the standard treatment for tuberculous meningitis, a serious brain infection. About 240 adults, including those living with HIV, will take part. The goal is to see if the new combo helps more people survive and recover better brain function.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease latent tuberculosis infection meningeal tuberculosis meningitis tuberculosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV MENINGITIS TB - TUBERCULOSIS TUBERCULOUS MENINGITIS

Contacts and locations

Locations

Infectious Diseases Institute
RECRUITING

Kampala, Uganda
Mbarara University of Science and Technology
RECRUITING

Mbarara, Uganda

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