Doxycycline's hidden effects on inflammation and microbiome under the microscope
NCT ID NCT07215325
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing whether the antibiotic doxycycline, already used to prevent bacterial STIs after sex, also changes inflammation levels and the natural bacteria in the body. Researchers will enroll 200 men, including those with HIV and those on PrEP, and measure immune markers and gut bacteria before and after taking doxycycline. The goal is to better understand the drug's broader effects, not to develop a new treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
doxycycline
What this could lead to
If successful, this could reveal whether doxycycline has hidden benefits or risks for inflammation and gut bacteria, informing future STI prevention strategies.
What could go wrong
This is a small, early-phase study focused on biological markers, not on curing or preventing disease. Results may not lead to any change in clinical practice.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Grady Health System (non-CRN)
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hope Clinic
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••