Doxycycline's hidden effects on inflammation and microbiome under the microscope

NCT ID NCT07215325

Recruiting now Knowledge-focused Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether the antibiotic doxycycline, already used to prevent bacterial STIs after sex, also changes inflammation levels and the natural bacteria in the body. Researchers will enroll 200 men, including those with HIV and those on PrEP, and measure immune markers and gut bacteria before and after taking doxycycline. The goal is to better understand the drug's broader effects, not to develop a new treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: doxycycline
What this could lead to: If successful, this could reveal whether doxycycline has hidden benefits or risks for inflammation and gut bacteria, informing future STI prevention strategies.
What could go wrong: This is a small, early-phase study focused on biological markers, not on curing or preventing disease. Results may not lead to any change in clinical practice.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease sexually transmitted disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SEXUALLY TRANSMITTED INFECTIONS (STI)

Contacts and locations

Locations

Grady Health System (non-CRN)
RECRUITING

Atlanta, Georgia, 30322, United States
Hope Clinic
RECRUITING

Atlanta, Georgia, 30322, United States

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