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Choice of Long-Acting HIV prevention could transform care for young people in rural south africa

NCT ID NCT06250504

Recruiting now Prevention Sponsor: Africa Health Research Institute Source: ClinicalTrials.gov ↗

First seen Jul 09, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This trial tests whether offering young people aged 15-30 in rural South Africa a choice of long-acting HIV prevention methods—such as a two-monthly injection or a vaginal ring—alongside standard daily pills and emergency prevention, increases how many start and stay on prevention. The study compares communities that receive this choice with those that only get daily pills, all through local sexual health services. The goal is to see if more options lead to better protection and lower rates of transmissible HIV in the community.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
cabotegravir (injectable), dapivirine vaginal ring, oral PrEP, and HIV PEP packs
What this could lead to
If successful, this approach could make HIV prevention more accessible and effective for young people in rural communities, reducing new infections.
What could go wrong
The trial is in a specific rural area, so results may not apply elsewhere. Uptake and retention may still be lower than hoped, and side effects or logistical challenges could limit impact.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV INFECTIONS

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Africa Health Research Institute

    RECRUITING

    Somkele, KwaZulu-Natal, South Africa

    Contact Email: •••••@•••••

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