Can a shot and a vaccine free people with HIV from daily pills? early trial aims to find out.
NCT ID NCT06484335
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-stage study tests whether giving two powerful antibodies along with a therapeutic HIV vaccine can help people with HIV control the virus after they stop their daily antiretroviral therapy. The trial enrolls 48 adults in Thailand who started HIV treatment very soon after infection. Participants will receive the antibodies and vaccine or placebos, then pause their regular HIV meds under close monitoring to see if the new approach keeps the virus in check.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
broadly neutralizing antibodies (VRC07-523LS and PGDM1400LS) and a therapeutic HIV vaccine (ChAdOx1/MVA-based)
What this could lead to
If it works, this could point toward a way for people with HIV to stop daily antiretroviral therapy and keep the virus under control.
What could go wrong
This is a very early Phase 1 safety trial with only 48 participants. The approach may not work, and participants will temporarily stop their regular HIV meds, which carries a risk of viral rebound.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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The Faculty of Medicine, Chulalongkorn University/ King Chulalongkorn Memorial Hospital
RECRUITINGPathum Wan, Bangkok, 10330, Thailand
Contact Phone: •••-•••-•••• Email: •••••@•••••