Can a shot and a vaccine free people with HIV from daily pills? early trial aims to find out.

NCT ID NCT06484335

Recruiting now Disease control Sponsor: Henry M. Jackson Foundation for the Advancement of Military Medicine Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This early-stage study tests whether giving two powerful antibodies along with a therapeutic HIV vaccine can help people with HIV control the virus after they stop their daily antiretroviral therapy. The trial enrolls 48 adults in Thailand who started HIV treatment very soon after infection. Participants will receive the antibodies and vaccine or placebos, then pause their regular HIV meds under close monitoring to see if the new approach keeps the virus in check.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: broadly neutralizing antibodies (VRC07-523LS and PGDM1400LS) and a therapeutic HIV vaccine (ChAdOx1/MVA-based)
What this could lead to: If it works, this could point toward a way for people with HIV to stop daily antiretroviral therapy and keep the virus under control.
What could go wrong: This is a very early Phase 1 safety trial with only 48 participants. The approach may not work, and participants will temporarily stop their regular HIV meds, which carries a risk of viral rebound.

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Conditions

The condition(s) this trial relates to.

Arts syndrome HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE HIV INFECTION ART HIV INFECTIONS PLWH

Contacts and locations

Locations

The Faculty of Medicine, Chulalongkorn University/ King Chulalongkorn Memorial Hospital
RECRUITING

Pathum Wan, Bangkok, 10330, Thailand

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