Could a vaccine combo free people with HIV from daily pills?
NCT ID NCT06071767
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a special T-cell vaccine, combined with an immune-boosting drug (vesatolimod) and two powerful antibodies, can help people with HIV control the virus without needing daily antiretroviral therapy. The trial involves 36 adults who started HIV treatment soon after infection and have been on stable therapy for at least a year. Participants will receive the vaccine regimen or a placebo, then temporarily stop their regular HIV meds to see if the new approach keeps the virus in check.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
T-cell vaccine (ChAdOx1-MVA/HIVconsvX), vesatolimod, and broadly neutralizing antibodies (GS-5423, GS-2872)
What this could lead to
If successful, this could point toward a way for people with HIV to stop daily antiretroviral therapy while keeping the virus under control.
What could go wrong
This is an early-phase trial with only 36 participants, so results may not apply broadly. The combination regimen is complex and may cause side effects or fail to control the virus.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Chapel Hill CRS
RECRUITINGChapel Hill, North Carolina, 27599, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Columbia Physicians & Surgeons CRS
RECRUITINGNew York, New York, 10032, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Houston AIDS Research Team CRS
RECRUITINGHouston, Texas, 77004, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS
NOT_YET_RECRUITINGRio de Janeiro, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Instituto de Pesquisas em AIDS do Rio Grande do Sul - IPARGS CRS
RECRUITINGPorto Alegre, Rio Grande do Sul, 91350-180, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Massachusetts General Hospital CRS (MGH CRS)
NOT_YET_RECRUITINGBoston, Massachusetts, 02114, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Northwestern University CRS
RECRUITINGChicago, Illinois, 60611, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ohio State University CRS
RECRUITINGColumbus, Ohio, 43210, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Penn Therapeutics CRS
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ponce de Leon Center CRS
RECRUITINGAtlanta, Georgia, 30308, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California, San Diego AntiViral Research Center CRS
RECRUITINGSan Diego, California, 92103, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Washington University Therapeutics CRS
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••