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HIV and lungs: botswana study seeks clues to COPD risk

NCT ID NCT07699614

Knowledge-focused Sponsor: Duke University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 13, 2026 · Last updated Jul 14, 2026 · Updated 1 time

Summary

This study investigates why people with HIV are more likely to develop chronic lung diseases like COPD. Researchers in Botswana will follow 900 adults aged 35 and older, with and without HIV, measuring lung function through activity tests and walking distance. The goal is to uncover the hidden factors that damage lungs in this population, potentially guiding future prevention efforts.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could reveal why HIV increases the risk of chronic lung diseases like COPD, pointing toward better prevention strategies.
What could go wrong
This is an observational study, not a treatment trial, so it will not directly improve health. Results may not apply to other populations or regions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 900 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2024

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults 35 years and above with documented HIV status and without recent/active respiratory illness or inability to perform spirometry.

Ages

35 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults 35 years of age or older * In case at a clinic in Botswana * Documented HIV status * Ability to provide informed consent Exclusion Criteria: * Respiratory infection in the prior 4 weeks * Active pulmonary tuberculosis * Inability to perform spirometry including eye, abdominal, or * Thoracic surgery or myocardial infarction in the prior 6 weeks * Pregnancy

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Conditions

The condition(s) this trial relates to.

chronic obstructive pulmonary disease HIV infectious disease obstructive lung disease restrictive pulmonary disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obstructive pulmonary disease Restrictive pulmonary disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Local Health Facilities in Gaborone

    RECRUITING

    Gaborone, 267, Botswana

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