Blood platelets may hold clues to HIV's hidden hideouts

NCT ID NCT07745530

Recruiting now Knowledge-focused Sponsor: Tourcoing Hospital Source: ClinicalTrials.gov ↗

First seen Aug 04, 2026 · Last updated Aug 05, 2026 · Updated 1 time

Summary

This study investigates whether platelets—tiny blood cells involved in clotting—interact with HIV-infected immune cells in ways that affect the virus's ability to persist despite treatment. Researchers will collect blood samples from 90 adults with HIV who have had undetectable viral loads for over two years. By examining how platelets bind to CD4+ T cells and whether they can reactivate dormant HIV, the study aims to understand why some people experience ongoing immune dysfunction even with successful therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: blood sampling
What this could lead to: If this works, it could point toward new ways to measure or target hidden HIV reservoirs, potentially improving immune recovery in people on antiretroviral therapy.
What could go wrong: This is an observational study, so it won't directly test a treatment. The findings may not lead to immediate clinical changes, and the role of platelets in HIV persistence remains uncertain.

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Conditions

The condition(s) this trial relates to.

AIDS HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV

Contacts and locations

Locations

Centre Hospitalier de Tourcoing
RECRUITING

Tourcoing, 59200, France

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