New brain scans may uncover hidden HIV damage
NCT ID NCT05586581
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study uses special PET scans to measure brain synapse density in people with HIV who are on effective treatment. Researchers want to understand why some still develop thinking or memory problems. They will compare 70 participants (with and without HIV) over two years using brain imaging and lab tests.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- PET radiotracers ([11C]UCB-J and [11C]PBR28)
- What this could lead to
- If successful, this could reveal why some people with HIV still have brain problems despite treatment, pointing toward future therapies.
- What could go wrong
- This is an early-phase imaging study with only 70 participants, so it won't directly test treatments. Results may not apply to everyone with HIV.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Yale School of Medicne, Neuro ID Research Program
RECRUITINGNew Haven, Connecticut, 06510, United States
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