New mRNA HIV vaccines enter human testing

NCT ID NCT07390474

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 07, 2026 · Updated 7 times

Summary

This early-stage trial tests two experimental mRNA vaccines designed to train the immune system to make special antibodies that could block HIV. The study involves 40 healthy adults without HIV who will receive the vaccines and be monitored for safety and immune responses. It is the first time these vaccines are being tested in humans.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mRNA vaccines (DV201P-RNA and DV202B1-RNA) designed to train the immune system to produce HIV-fighting antibodies
What this could lead to: If successful, this could point toward a vaccine that helps prevent HIV infection by teaching the body to make powerful antibodies.
What could go wrong: This is a very early, small Phase 1 trial focused on safety, not effectiveness. The vaccines may not trigger the desired immune response or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV

Contacts and locations

Locations

Beth Israel Deaconess Medical Center VCRS (BIDMC VCRS Site # 32077)
RECRUITING

Boston, Massachusetts, 02215, United States
Columbia P&S CRS (Site ID: 30329)
RECRUITING

New York, New York, 10032, United States
Penn Prevention CRS (Site ID 30310)
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
The Hope Clinic of the Emory Vaccine Research Center; Emory University
RECRUITING

Decatur, Georgia, 30030, United States
The Ponce de Leon Center CRS (Site ID 5802)
RECRUITING

Atlanta, Georgia, 30308, United States
University of Pittsburgh CRS
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Rochester Vaccines to Prevent HIV Infection CRS (Site ID 31467)
RECRUITING

Rochester, New York, 14642, United States

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