Engineered immune cells take on HIV-Linked cancers in first human trial

NCT ID NCT05077527

Recruiting now Disease control Sponsor: AIDS Malignancy Consortium Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 1 time

Summary

This study tests a CAR-T cell therapy (axicabtagene ciloleucel) in 20 HIV-positive adults whose aggressive B-cell lymphoma has come back or stopped responding to standard treatment. The therapy uses a patient's own immune cells, modified to recognize and attack cancer cells. The main goals are to see if the treatment is safe and possible to deliver in this group.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for AIDS-RELATED DIFFUSE LARGE B-CELL LYMPHOMA are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

AIDS-related primary central nervous system lymphoma B-cell non-Hodgkin lymphoma diffuse large B-cell lymphoma follicular lymphoma high grade B-cell lymphoma HIV infectious disease non-Hodgkin lymphoma primary mediastinal large B-cell lymphoma refractory malignant neoplasm relapsed/refractory diffuse large B-cell lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AIDS-RELATED DIFFUSE LARGE B-CELL LYMPHOMA AIDS-RELATED NON-HODGKIN LYMPHOMA HIV INFECTION RECURRENT DIFFUSE LARGE B-CELL LYMPHOMA RECURRENT GRADE 3B FOLLICULAR LYMPHOMA RECURRENT HIGH-GRADE B-CELL LYMPHOMA RECURRENT NON-HODGKIN LYMPHOMA RECURRENT PRIMARY MEDIASTINAL (THYMIC) LARGE B-CELL LYMPHOMA RECURRENT TRANSFORMED B-CELL NON-HODGKIN LYMPHOMA REFRACTORY DIFFUSE LARGE B-CELL LYMPHOMA REFRACTORY GRADE 3B FOLLICULAR LYMPHOMA REFRACTORY HIGH-GRADE B-CELL LYMPHOMA REFRACTORY NON-HODGKIN LYMPHOMA REFRACTORY PRIMARY MEDIASTINAL (THYMIC) LARGE B-CELL LYMPHOMA REFRACTORY TRANSFORMED B-CELL NON-HODGKIN LYMPHOMA

Contacts and locations

Locations

City of Hope Comprehensive Cancer Center
RECRUITING

Duarte, California, 91010, United States
Huntsman Cancer Institute, University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Montefiore Medical Center - Moses Campus
RECRUITING

The Bronx, New York, 10467, United States
The Ohio state University
RECRUITING

Columbus, Ohio, 43210, United States
University of Illinois at Chicago
RECRUITING

Chicago, Illinois, 60612, United States
University of Pennsylvania / Abramson Cancer Center
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.