HIV breakthrough trial seeks to rescue failing treatments in africa

NCT ID NCT05373758

Recruiting now Disease control Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests different approaches to help people with HIV whose current medication (tenofovir, lamivudine, and dolutegravir, or TLD) is no longer working. It involves 648 adults and teens in Uganda and South Africa. The goal is to find the best strategy to get the virus under control again, measured by a very low viral load after 48 weeks.

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Conditions

The condition(s) this trial relates to.

AIDS HIV infectious disease Medication Adherence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AIDS HIV INFECTIONS VIROLOGIC FAILURE

Contacts and locations

Locations

Mbarara City Clinic
RECRUITING

Mbarara, Uganda
Mbarara Regional Referral Hospital Immune Suppression Syndrome Clinic
RECRUITING

Mbarara, Uganda
RK Khan Hospital Clinic
RECRUITING

Durban, South Africa

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