Can stimulating a nerve calm HIV-Related inflammation?
NCT ID NCT04353778
First seen Jun 24, 2026 · Last updated Jun 24, 2026
Summary
This study looks at how damage to the vagus nerve may cause gut issues and inflammation in people with HIV. Researchers will test two approaches—a drug called pyridostigmine and non-invasive vagus nerve stimulation—to see if they can improve gut function and reduce inflammation. The study involves 207 participants and aims to better understand these pathways.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Icahn School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 10029, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
pyridostigmine
What this could lead to
If successful, this could point toward new ways to reduce inflammation and gut problems in people living with HIV.
What could go wrong
This is an early-phase study focused on understanding mechanisms, not proving a treatment works. The results may not lead to a direct therapy.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.