Can stimulating a nerve calm HIV-Related inflammation?
NCT ID NCT04353778
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at how damage to the vagus nerve may cause gut issues and inflammation in people with HIV. Researchers will test two approaches—a drug called pyridostigmine and non-invasive vagus nerve stimulation—to see if they can improve gut function and reduce inflammation. The study involves 207 participants and aims to better understand these pathways.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- pyridostigmine
- What this could lead to
- If successful, this could point toward new ways to reduce inflammation and gut problems in people living with HIV.
- What could go wrong
- This is an early-phase study focused on understanding mechanisms, not proving a treatment works. The results may not lead to a direct therapy.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Icahn School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 10029, United States
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