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Could a weekly pill replace daily HIV treatment? new study aims to find out.

NCT ID NCT07266831

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 6 times

Summary

This study tests whether a once-weekly combination of two experimental drugs (islatravir and ulonivirine) works as well as the standard daily three-drug pill Biktarvy for people newly diagnosed with HIV-1. About 570 adults who have never taken HIV medication will be randomly assigned to one of the two treatments. The main goals are to see if the weekly pill can keep the virus under control and to check its safety and side effects.

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Conditions

The condition(s) this trial relates to.

AIDS HIV infectious disease Infections

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1) INFECTION

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Atrium Health Infectious Disease Kenilworth - Charlotte ( Site 1533)

    RECRUITING

    Charlotte, North Carolina, 28204, United States

  • Be Part Yoluntu Centre ( Site 4300)

    RECRUITING

    Mbekweni, Paarl, Western Cape, 7646, South Africa

  • Biomedica Research Group ( Site 4201)

    RECRUITING

    Santiago, Region M. de Santiago, 7500710, Chile

  • Bordeaux University Hospital - Pellegrin ( Site 3605)

    RECRUITING

    Bordeaux, Gironde, 33076, France

  • CAN Community Health ( Site 1510)

    RECRUITING

    Sarasota, Florida, 34237, United States

  • CAN Community Health- Miami Gardens ( Site 1549)

    RECRUITING

    Miami Gardens, Florida, 33055, United States

  • CELAN,S.A ( Site 3802)

    RECRUITING

    Guatemala City, 01010, Guatemala

  • Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu-Infectious Disease ( Site 3606)

    RECRUITING

    Nantes, Pays de la Loire Region, 44093, France

  • Centre Hospitalier Universitaire de Toulouse - Hôpital Purpan ( Site 3608)

    RECRUITING

    Toulouse, Haute-Garonne, 31059, France

  • Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada ( Site 3102)

    RECRUITING

    Caba, Buenos Aires, C1425AGC, Argentina

  • Clínica Mayo de Urgencias Médicas Cruz Blanca S.R.L ( Site 3105)

    RECRUITING

    San Miguel de Tucumán, Tucumán Province, T4000IHE, Argentina

  • Clínica Médica Especializada en Pediatría e Infectología Pediátrica - Dr. Mario Melgar ( Site 3801)

    RECRUITING

    Guatemala City, 01009, Guatemala

  • Clínica Universidad de Los Andes ( Site 4207)

    RECRUITING

    Santiago, Region M. de Santiago, 7620157, Chile

  • Complejo Hospitalario Virgen De La Victoria ( Site 3409)

    RECRUITING

    Málaga, 29010, Spain

  • Consorcio Hospital General Universitario de Valencia ( Site 3406)

    RECRUITING

    Valencia, Valenciana, Comunitat, 46014, Spain

  • DCOL Center for Clinical Research ( Site 1511)

    RECRUITING

    Longview, Texas, 75605, United States

  • Espacio Eme ( Site 4202)

    ACTIVE_NOT_RECRUITING

    Santiago, Region M. de Santiago, 7770086, Chile

  • Fundación Huesped ( Site 3100)

    RECRUITING

    CABA, Buenos Aires, C1427CEA, Argentina

  • Fundación IDEAA ( Site 3101)

    RECRUITING

    Buenos Aires, Buenos Aires F.D., C1405CKC, Argentina

  • Gestion clinique médicale l'Actuel ( Site 3303)

    RECRUITING

    Montreal, Quebec, H2L 4P9, Canada

  • HOPITAL DE LA CROIX ROUSSE ( Site 3613)

    RECRUITING

    Lyon, Rhone, 69317, France

  • HOSPITAL CLÍNIC DE BARCELONA ( Site 3400)

    RECRUITING

    Barcelona, 08036, Spain

  • Harborview Medical Center ( Site 1526)

    RECRUITING

    Seattle, Washington, 98104, United States

  • Henry Ford Hospital ( Site 1535)

    RECRUITING

    Detroit, Michigan, 48202, United States

  • Hospital Universitari Vall d'Hebron ( Site 3402)

    RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre ( Site 3405)

    RECRUITING

    Madrid, 28041, Spain

  • Hospital Universitario La Paz ( Site 3404)

    RECRUITING

    Madrid, Madrid, Comunidad de, 28029, Spain

  • Hôpital Avicenne ( Site 3602)

    RECRUITING

    Bobigny, Île-de-France Region, 93000, France

  • Hôpital Bichat - Claude-Bernard ( Site 3601)

    RECRUITING

    Paris, Île-de-France Region, 75018, France

  • Hôpital Saint-Louis ( Site 3600)

    RECRUITING

    Paris, Île-de-France Region, 75010, France

  • ID Care ( Site 1507)

    RECRUITING

    Hillsborough, New Jersey, 08844, United States

  • Instituto CAICI SRL ( Site 3106)

    RECRUITING

    Rosario, Santa Fe Province, S2000PBJ, Argentina

  • Instituto de Investigaciones Clinicas Mar del Plata ( Site 3103)

    RECRUITING

    Mar del Plata, Buenos Aires, B7600FZN, Argentina

  • Josha Research ( Site 4302)

    RECRUITING

    Bloemfontein, Free State, 9301, South Africa

  • KC CARE Health Center ( Site 1506)

    RECRUITING

    Kansas City, Missouri, 64111, United States

  • MEDI-K ( Site 3803)

    RECRUITING

    Guatemala City, 01009, Guatemala

  • Mercer university, Department of internal medicine-Clinical Research ( Site 1512)

    RECRUITING

    Macon, Georgia, 31201, United States

  • Metro Infectious Diseases Consultants L.L.C. ( Site 1509)

    RECRUITING

    Decatur, Georgia, 30033, United States

  • Midway Immunology and Research Center ( Site 1503)

    RECRUITING

    Ft. Pierce, Florida, 34982, United States

  • Morales Vargas Centro de Investigacion, S.C. ( Site 4502)

    RECRUITING

    León, Guanajuato, 37000, Mexico

  • North Texas Infectious Diseases Consultants ( Site 1500)

    ACTIVE_NOT_RECRUITING

    Dallas, Texas, 75246, United States

  • Orlando Immunology Center ( Site 1501)

    RECRUITING

    Orlando, Florida, 32803, United States

  • Prism Health North Texas, Oak Cliff Health Center ( Site 1514)

    RECRUITING

    Dallas, Texas, 75208, United States

  • Regional Center for Infectious Diseases ( Site 1516)

    RECRUITING

    Greensboro, North Carolina, 27401, United States

  • Ruane Clinical Research Group, Inc. ( Site 1513)

    RECRUITING

    Los Angeles, California, 90036, United States

  • Rush University Medical Center-Infectious Disease ( Site 1522)

    RECRUITING

    Chicago, Illinois, 60612, United States

  • Saint Hope Foundation, Inc. ( Site 1504)

    RECRUITING

    Bellaire, Texas, 77401, United States

  • Spectrum Health ( Site 3307)

    RECRUITING

    Vancouver, British Columbia, V6Z 2T1, Canada

  • Texas Center for Infectious Disease Associates ( Site 1502)

    RECRUITING

    Fort Worth, Texas, 76104, United States

  • The Ohio State University ( Site 1536)

    RECRUITING

    Columbus, Ohio, 43210, United States

  • Triple O Research Institute ( Site 1505)

    RECRUITING

    West Palm Beach, Florida, 33407, United States

  • University of Pennsylvania Perelman School of Medicine ( Site 1508)

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Vivent Health ( Site 1519)

    RECRUITING

    Denver, Colorado, 80246, United States

  • Wentworth Hospital ( Site 4303)

    RECRUITING

    Durban, KwaZulu-Natal, 4052, South Africa

  • Whitman-Walker Institute ( Site 1538)

    RECRUITING

    Washington D.C., District of Columbia, 20032, United States

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