Video game aims to lift depression in teens with HIV

NCT ID NCT06389565

Recruiting now Symptom relief Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 07, 2026 · Updated 3 times

Summary

This pilot study tests a mobile game called Change My Story, designed to help young people (ages 16-24) living with HIV who also have depression. The game uses a choose-your-own-adventure format to teach coping skills, and is combined with problem-solving therapy. Researchers will compare this combo to therapy alone in 80 participants in Nigeria, measuring engagement, satisfaction, and whether depression improves.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Change My Story (narrative game) plus Problem Solving Therapy
What this could lead to: If it works, this could offer a low-cost, stigma-free way to improve mental health and HIV outcomes for young people in low-resource settings.
What could go wrong: This is a small pilot study (80 people) testing feasibility and satisfaction, not yet effectiveness. The game may not engage users or improve depression more than therapy alone.

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Conditions

The condition(s) this trial relates to.

AIDS Depression depressive disorder HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION HIV PSYCHOLOGICAL DISTRESS

Contacts and locations

Locations

University of Ibadan
RECRUITING

Ibadan, Oyo State, Nigeria

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