PSYCHOLOGICAL DISTRESS

This study tests a therapy called EMDR (eye movement desensitization and reprocessing) to see if it can reduce post-traumatic stress and emotional distress in people with advanced thyroid cancer. About 25 participants will receive both group and individual EMDR sessions. The goal…

This study tests whether a 10-day meditation app can lower anxiety and depression in firefighters. About 192 career firefighters will use pre-recorded audio sessions on their smartphones. The goal is to see if this simple, at-home tool can ease the mental strain of their demandin…

This study tests a therapy called EMDR Toolbox to see if it can improve the emotional well-being of people with cancer. The therapy helps process difficult life experiences that may add to stress. About 46 adults with early-stage cancer will receive either standard EMDR or the EM…

This study tests whether a free online program from the World Health Organization, called Doing What Matters in Times of Stress, can help reduce anxiety and depression in employees of small and medium-sized Dutch companies. About 518 workers with high stress levels will either ge…

This study tests a short, guided self-help program called Self-Help Plus for university students who are behind on at least 3 exams and feeling significant distress. About 210 students will be randomly assigned to the program or usual support. The goal is to see if the program re…

This study tests whether a special, soothing way of talking called hypnotic communication can help patients feel less anxious and stressed during a heart catheterization. About 306 adults will be randomly assigned to receive either this calming talk plus usual care, or usual care…

This study tests whether a therapy called Mindful Self-Compassion (MSC) can help people with borderline personality disorder (BPD) feel better. Researchers will enroll 60 adults with BPD to see if MSC reduces self-harm, improves emotional control, and boosts quality of life. The …

This study tests a 12-session training program that uses heart rate feedback to help security personnel manage stress and prevent burnout. Fifty Portuguese National Guard members will learn breathing and relaxation techniques. The goal is to see if this approach reduces psycholog…

This study tests whether adding extra booster sessions and homework reminders to a short psychological program (PM+) can better reduce stress, anxiety, and trauma symptoms in refugees and asylum seekers. About 1,200 participants aged 16 and older from Swiss communities will take …

This study tests whether very small, non-hallucinogenic doses of psilocybin (the active ingredient in 'magic mushrooms') can reduce depression, anxiety, and loss of purpose in 120 adults with advanced illness who are under palliative care. Participants take either psilocybin or a…

This study tests whether moderate to high doses of LSD can reduce anxiety, depression, and pain in people with advanced, life-limiting illnesses. Sixty participants with a life expectancy of 12 weeks to 2 years will receive either two doses of LSD or a very low dose as a placebo.…

This study tests a short therapy program for young adults (ages 25-39) with cancer and their partners. The goal is to see if it helps them cope with stress and stay connected as a couple. About 20 couples will take part in 8 sessions. The study focuses on whether people find it h…

This study is testing a new community-based program to help Black transgender women who experience ongoing stigma. The program aims to reduce symptoms of stress, anxiety, and depression. Researchers will work with 40 participants to see if the program is helpful and practical.

This study is testing a smartphone app powered by artificial intelligence to help people with oral cancer return to work and manage physical and emotional challenges. Researchers will compare 650 patients who use the app with those who receive standard care. The goal is to see if…

This observational study follows 340 people receiving psychotherapy for common mental health problems in Ecuador. Participants fill out short well-being questionnaires before their regular therapy sessions. The goal is to understand how much distress typically changes and what fa…

This study tests a digital program called Flourish designed to help teens aged 12-17 who have been cyberbullied and are at risk for suicide. About 80 teens will either use Flourish plus answer questionnaires or just answer questionnaires alone. Researchers want to see if the prog…

This study tests a digital program called Flourish designed to help teens who are cyberbullied and having suicidal thoughts. Researchers will work with 20 middle and high school students to see if the program is easy to use in schools and if it reduces distress and suicidal thoug…

This study follows 2,000 adults with various cancers to see if psychological distress (like anxiety or depression) impacts how well they stick to treatment, how their tumors respond, and their overall quality of life. Participants complete questionnaires and are monitored for thr…

This study looks at how many adults with type 2 diabetes experience severe emotional distress related to their condition. Researchers at a French hospital will ask 246 participants to fill out questionnaires about their feelings, quality of life, and diet. The goal is to find out…

This pilot study looks at how often women experience posttraumatic stress disorder (PTSD) after having gynecologic brachytherapy implants removed. Researchers want to find ways to improve comfort and reduce psychological distress during the removal process. About 36 women who hav…

This study aims to see if community-based mental health services can improve depression, anxiety, and PTSD. About 1,000 adults with mild to moderate psychological distress will receive these services and be tracked over time. The goal is to learn what works best to support mental…