PSYCHOLOGICAL DISTRESS

This trial tests two ways to bring nature to older adults stuck in the hospital for weeks: watching 360-degree nature videos through a virtual reality headset, or listening to audio guides that prompt them to imagine the same scenes. Both approaches use identical nature themes—me…

This trial tests whether a culturally adapted, nurse-led program called COPE can improve the psychological wellbeing of primary caregivers of children with autism spectrum disorder in Pakistan. The program includes four weekly sessions focused on coping skills, emotional regulati…

This study will test whether a smartphone meditation program called Equa can help young adults (ages 18-30) reduce stress, anxiety, and loneliness. About 300 participants will use the app for 14 days, completing short daily guided lessons while wearing sensors to track their body…

This study tests whether adding real-time breathing feedback to a meditation app helps young adults (ages 18–30) with psychological distress improve their mindfulness skills. Participants complete 14 short guided meditation sessions on their phone while their breathing and moveme…

This study tests whether a free online program from the World Health Organization, called 'Doing What Matters in Times of Stress,' can help reduce anxiety and depression in employees of small and medium-sized Dutch companies. About 518 workers with elevated stress levels will eit…

This phase 3 trial tests whether daily low-dose psilocybin (2-3 mg) can reduce psychological distress in 120 adults with advanced illness who have 2-12 months to live. Participants take the drug four days a week for two weeks, without therapy. The study compares psilocybin to a p…

This study tests a structured program designed to help emergency nurses cope with the psychological impact of repeatedly witnessing traumatic events. The program combines education, mindfulness, and peer support to reduce distress and promote positive growth. Sixty nurses from em…

This pilot study tests a mobile game called Change My Story, designed to help young people (ages 16-24) living with HIV who also have depression. The game uses a choose-your-own-adventure format to teach coping skills, and is combined with problem-solving therapy. Researchers wil…

This study tests a group therapy program called TAG TEAM for trans and gender diverse teens aged 12-17. The program helps them understand and cope with stress from discrimination and rejection. Researchers will compare the program to a waitlist to see if it reduces anxiety, depre…

This study is testing a smartphone app that uses artificial intelligence to help people with oral cancer manage symptoms, improve communication, and return to work. The app includes a chatbot for emotional support, posture correction exercises, and a communication aid. Researcher…

This study tests whether adding booster sessions and homework reminders to a short psychological program (PM+) can further reduce stress, PTSD, and other mental health problems in refugees and asylum seekers. About 1,200 participants in Switzerland will receive the enhanced suppo…

This study tests whether low or moderate doses of LSD can reduce anxiety, pain, and depression in people with advanced or terminal illnesses. Sixty participants will receive either two moderate doses or two very low (placebo-like) doses of LSD in a double-blind setup. The goal is…

This study tests a therapy called EMDR Toolbox to see if it can improve the psychological well-being of people with early-stage cancer. About 46 participants will receive either standard EMDR or the enhanced Toolbox method over 15 sessions. The goal is to reduce distress, anxiety…

This study tests a brief guided self-help program called Self-Help Plus for university students who are behind on at least three exams and feeling distressed. The program teaches coping skills based on acceptance and commitment therapy. Researchers will measure changes in distres…

This pilot study is testing whether a therapy called EMDR (eye movement desensitization and reprocessing) can help reduce post-traumatic stress and psychological distress in people with advanced thyroid cancer. The study will enroll 25 participants who have cancer and PTSD sympto…

This study tests a simple, drug-free method called hypnotic communication to help patients feel calmer during a heart procedure (coronary angiography). About 306 adults will either receive this special calming talk from a nurse or standard care. The goal is to see if it reduces s…

This study tests a 12-session training program that uses heart rate feedback to help security personnel manage stress and prevent burnout. About 50 Portuguese National Guard members will learn breathing techniques to improve their body's stress response. The goal is to see if thi…

This study tests a behavioral program designed to reduce psychological distress (PTSD and depression) in Black transgender women who experience chronic stigma. The program includes weekly group sessions led by a community member and a nurse, plus online educational materials and …

This pilot study tests a brief psychotherapy program for young adults (ages 25-39) with cancer and their caregiving partners. The therapy uses cognitive-behavioral and couples therapy techniques to improve coping and maintain the relationship. The study will enroll 20 couples to …

This study tests whether a 10-day meditation program delivered through a smartphone app can reduce anxiety and depression in firefighters. About 192 career firefighters will either use the meditation app or a health education app for 10 days. Researchers will measure changes in d…

This study tests whether a routine digital screening followed by a supportive phone call can help cancer survivors get the emotional and social support they need after finishing primary treatment. Fifty adults who have completed cancer therapy will take part. The goal is to see i…

This pilot study looks at how often women experience posttraumatic stress disorder (PTSD) after gynecologic brachytherapy, a type of internal radiation. Researchers want to find better ways to keep patients comfortable and reduce psychological distress when the treatment applicat…

This study tests a digital program called Flourish (formerly imHere4U) designed to help teens aged 12-17 who have been cyberbullied and are at risk for suicide. About 80 teens will be randomly assigned to either use Flourish plus fill out questionnaires or just fill out questionn…

This study aims to find out how many adults with type 2 diabetes experience severe diabetes-related distress—a feeling of being overwhelmed by the demands of managing the disease. Researchers at a French hospital will ask 246 participants to fill out questionnaires about their em…

This study tests a digital program called Flourish that aims to prevent suicide in teens who are bullied online. About 20 middle and high school students will use the program for 12 weeks. Researchers will see if it reduces distress and suicidal thoughts, and if schools can easil…

This study follows 340 people receiving routine psychotherapy in Ecuador to see how their psychological distress changes over time. Participants simply fill out short questionnaires before each session. The goal is to learn what factors are linked to better outcomes in real-world…

This study follows 2,000 adults with various cancers to see if psychological distress (anxiety or depression) affects how well they stick to treatment, their health outcomes, and their quality of life. Participants complete standard questionnaires (GAD-7 and PHQ-9) and are tracke…