New antibody cocktail aims to block HIV without daily pills
NCT ID NCT07390955
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-stage trial is testing whether lab-made antibodies that target HIV are safe and how long they stay in the body. About 83 healthy adults without HIV will receive the antibodies by vein or under the skin, alone or in combination. The goal is to find the right dose and check for side effects, not to treat HIV yet.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
lab-made antibodies (ePGT121v1-LS, PGDM1400LS, VRC07-523LS)
What this could lead to
If successful, this could point toward a new way to control HIV without daily pills, using periodic antibody infusions or shots.
What could go wrong
This is a very early Phase 1 safety study with only 83 healthy volunteers, not people with HIV. It is too soon to know if the antibodies will work against the virus in real-world conditions.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Alabama CRS (Site ID: 31788)
RECRUITINGBirmingham, Alabama, 35222, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Bridge HIV CRS (Site ID: 30305)
RECRUITINGSan Francisco, California, 94102, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Brigham and Women's Hospital Vaccine CRS (BWH VCRS) (Site ID: 30007)
NOT_YET_RECRUITINGBoston, Massachusetts, 02115, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Centro de Investigaciones Tecnológicas, Biomédicas y Medioambientales CRS (CITBM) - Unidad de Ensayos Clínicos (UNIDEC) (Site ID: 31970)
NOT_YET_RECRUITINGBellavista, Provincia Constitucional del Callao, 07006, Peru
Contact Phone: •••-•••-•••• Email: •••••@•••••
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George Washington University CRS (Site ID: 31608)
NOT_YET_RECRUITINGWashington D.C., District of Columbia, 20052, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Houston Advancing Research Team CRS (Site ID: 31473)
NOT_YET_RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Penn Prevention CRS (Site ID: 30310)
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Seke South CRS (Site ID: 30294)
NOT_YET_RECRUITINGHarare, Zimbabwe
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Spilhaus CRS (Site ID: 30314)
NOT_YET_RECRUITINGHarare, Zimbabwe
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Ponce de Leon Center CRS (Site ID: 5802)
NOT_YET_RECRUITINGAtlanta, Georgia, 30308, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vanderbilt Vaccine (VV) CRS (Site ID: 30352)
RECRUITINGNashville, Tennessee, 37232, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Via Libre CRS (Site ID: 31909)
NOT_YET_RECRUITINGLima Cercado, Lima region, 15001, Peru
Contact Phone: •••-•••-•••• Email: •••••@•••••