Could a monthly shot stop fentanyl overdoses in cocaine and meth users?

NCT ID NCT06633900

Recruiting now Prevention Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a monthly injection of naltrexone can prevent fentanyl overdose in people who use stimulants like cocaine or methamphetamine but do not intentionally use opioids. One hundred participants will either receive the shot or standard harm reduction supplies. Researchers will track how many people stick with the treatment and whether it reduces overdose events.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: naltrexone injection
What this could lead to: If it works, this could offer a new way to prevent opioid overdoses in people who use stimulants and may be unknowingly exposed to fentanyl.
What could go wrong: This is a mid-stage trial with only 100 participants, so results may not apply to everyone. The drug only works if taken consistently, and it cannot reverse an overdose once it happens.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease poisoning acute opioid poisoning prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVERDOSE ACCIDENTAL

Contacts and locations

Locations

Center on Substance Use and Health
RECRUITING

San Francisco, California, 94102, United States

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