Can two antibodies help people with HIV ditch daily pills?
NCT ID NCT05719441
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether giving two powerful HIV-fighting antibodies along with standard HIV medication (ART) to people diagnosed very early with HIV can help them control the virus without daily pills later. 48 adults with acute HIV infection will receive either the antibodies or a placebo, plus ART. After a period, they will stop ART under close monitoring to see if the antibodies keep the virus suppressed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
HIV-specific broadly neutralizing monoclonal antibodies (VRC07-523LS and PGT121.414.LS) plus standard antiretroviral therapy (Biktarvy)
What this could lead to
If successful, this approach could allow people with HIV to stop daily medication and stay virus-free for long periods, pointing toward a functional cure.
What could go wrong
This is an early phase 2 trial with only 48 participants, so results may not apply broadly. The antibodies may not prevent viral rebound, and there is a risk of side effects like infusion reactions.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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1001, University of Pittsburgh CRS
NOT_YET_RECRUITINGPittsburgh, Pennsylvania, 15213, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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101, Massachusetts General Hospital CRS (MGH CRS)
NOT_YET_RECRUITINGBoston, Massachusetts, 02114, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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107, Brigham and Women's Hospital Therapeutics (BWH TCRS) CRS
NOT_YET_RECRUITINGBoston, Massachusetts, 02115, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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11301, Barranco CRS
NOT_YET_RECRUITINGLima, 4, Peru
Contact Phone: •••-•••-•••• Email: •••••@•••••
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11302, San Miguel CRS
NOT_YET_RECRUITINGSan Miguel, Lima region, 32, Peru
Contact Phone: •••-•••-•••• Email: •••••@•••••
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1201, University of Southern California CRS
NOT_YET_RECRUITINGLos Angeles, California, 90033-1079, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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12101, Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS
RECRUITINGRio de Janeiro, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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12201, Hospital Nossa Senhora da Conceicao CRS
NOT_YET_RECRUITINGPorto Alegre, 91350-200, Brazil
Contact Phone: •••-•••-•••• Email: •••••@•••••
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1401, University of Washington Positive Research CRS
RECRUITINGSeattle, Washington, 98104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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201, Johns Hopkins University CRS
NOT_YET_RECRUITINGBaltimore, Maryland, 21205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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2101, Washington University Therapeutics (WT) CRS
NOT_YET_RECRUITINGSt Louis, Missouri, 63110-1010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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2301, Ohio State University CRS
RECRUITINGColumbus, Ohio, 43210-1282, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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2401, Cincinnati CRS
NOT_YET_RECRUITINGCincinnati, Ohio, 45267-0405, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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2501, Case CRS
NOT_YET_RECRUITINGCleveland, Ohio, 44106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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2701, Northwestern University CRS
NOT_YET_RECRUITINGChicago, Illinois, 60611, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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2702, Rush University CRS
NOT_YET_RECRUITINGChicago, Illinois, 60612, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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2951, The Miriam Hospital (TMH) CRS
NOT_YET_RECRUITINGProvidence, Rhode Island, 02904, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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30329, Columbia Physicians & Surgeons (P&S) CRS
NOT_YET_RECRUITINGNew York, New York, 10032-3732, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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31443, Trinity Health and Wellness Center CRS
NOT_YET_RECRUITINGDallas, Texas, 75208, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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31473, Houston AIDS Research Team CRS
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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31786, New Jersey Medical School Clinical Research Center CRS
NOT_YET_RECRUITINGNewark, New Jersey, 07103, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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31787, University of Rochester Adult HIV Therapeutic Strategies Network CRS
NOT_YET_RECRUITINGRochester, New York, 14642, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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31788, Alabama CRS
NOT_YET_RECRUITINGBirmingham, Alabama, 35222, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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31791, Whitman-Walker Institute, Inc. CRS
NOT_YET_RECRUITINGWashington D.C., District of Columbia, 20005, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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3201, Chapel Hill CRS
NOT_YET_RECRUITINGChapel Hill, North Carolina, 27599-7215, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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3203, Greensboro CRS
NOT_YET_RECRUITINGGreensboro, North Carolina, 27401, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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3652, Vanderbilt Therapeutics (VT) CRS
NOT_YET_RECRUITINGNashville, Tennessee, 37204, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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5802, The Ponce de Leon Center CRS
RECRUITINGAtlanta, Georgia, 30308-2012, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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601, University of California, Los Angeles CARE Center CRS
NOT_YET_RECRUITINGLos Angeles, California, 90035, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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603, Harbor University of California Los Angeles Center CRS
NOT_YET_RECRUITINGTorrance, California, 90502, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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6101, University of Colorado Hospital CRS
RECRUITINGAurora, Colorado, 80045, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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6201, Penn Therapeutics CRS
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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701, UCSD Antiviral Research Center CRS
NOT_YET_RECRUITINGSan Diego, California, 92103, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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7803, Weill Cornell Uptown CRS
NOT_YET_RECRUITINGNew York, New York, 10065, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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7804, Weill Cornell Chelsea CRS
NOT_YET_RECRUITINGNew York, New York, 10010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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801, University of California, San Francisco HIV/AIDS CRS
NOT_YET_RECRUITINGSan Francisco, California, 94110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••