Can two antibodies help people with HIV ditch daily pills?

NCT ID NCT05719441

Recruiting now Disease control Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether giving two powerful HIV-fighting antibodies along with standard HIV medication (ART) to people diagnosed very early with HIV can help them control the virus without daily pills later. 48 adults with acute HIV infection will receive either the antibodies or a placebo, plus ART. After a period, they will stop ART under close monitoring to see if the antibodies keep the virus suppressed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HIV-specific broadly neutralizing monoclonal antibodies (VRC07-523LS and PGT121.414.LS) plus standard antiretroviral therapy (Biktarvy)
What this could lead to: If successful, this approach could allow people with HIV to stop daily medication and stay virus-free for long periods, pointing toward a functional cure.
What could go wrong: This is an early phase 2 trial with only 48 participants, so results may not apply broadly. The antibodies may not prevent viral rebound, and there is a risk of side effects like infusion reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE HIV INFECTION

Contacts and locations

Locations

1001, University of Pittsburgh CRS
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
101, Massachusetts General Hospital CRS (MGH CRS)
NOT_YET_RECRUITING

Boston, Massachusetts, 02114, United States
107, Brigham and Women's Hospital Therapeutics (BWH TCRS) CRS
NOT_YET_RECRUITING

Boston, Massachusetts, 02115, United States
11301, Barranco CRS
NOT_YET_RECRUITING

Lima, 4, Peru
11302, San Miguel CRS
NOT_YET_RECRUITING

San Miguel, Lima region, 32, Peru
1201, University of Southern California CRS
NOT_YET_RECRUITING

Los Angeles, California, 90033-1079, United States
12101, Instituto de Pesquisa Clinica Evandro Chagas (IPEC) CRS
RECRUITING

Rio de Janeiro, Brazil
12201, Hospital Nossa Senhora da Conceicao CRS
NOT_YET_RECRUITING

Porto Alegre, 91350-200, Brazil
1401, University of Washington Positive Research CRS
RECRUITING

Seattle, Washington, 98104, United States
201, Johns Hopkins University CRS
NOT_YET_RECRUITING

Baltimore, Maryland, 21205, United States
2101, Washington University Therapeutics (WT) CRS
NOT_YET_RECRUITING

St Louis, Missouri, 63110-1010, United States
2301, Ohio State University CRS
RECRUITING

Columbus, Ohio, 43210-1282, United States
2401, Cincinnati CRS
NOT_YET_RECRUITING

Cincinnati, Ohio, 45267-0405, United States
2501, Case CRS
NOT_YET_RECRUITING

Cleveland, Ohio, 44106, United States
2701, Northwestern University CRS
NOT_YET_RECRUITING

Chicago, Illinois, 60611, United States
2702, Rush University CRS
NOT_YET_RECRUITING

Chicago, Illinois, 60612, United States
2951, The Miriam Hospital (TMH) CRS
NOT_YET_RECRUITING

Providence, Rhode Island, 02904, United States
30329, Columbia Physicians & Surgeons (P&S) CRS
NOT_YET_RECRUITING

New York, New York, 10032-3732, United States
31443, Trinity Health and Wellness Center CRS
NOT_YET_RECRUITING

Dallas, Texas, 75208, United States
31473, Houston AIDS Research Team CRS
RECRUITING

Houston, Texas, 77030, United States
31786, New Jersey Medical School Clinical Research Center CRS
NOT_YET_RECRUITING

Newark, New Jersey, 07103, United States
31787, University of Rochester Adult HIV Therapeutic Strategies Network CRS
NOT_YET_RECRUITING

Rochester, New York, 14642, United States
31788, Alabama CRS
NOT_YET_RECRUITING

Birmingham, Alabama, 35222, United States
31791, Whitman-Walker Institute, Inc. CRS
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20005, United States
3201, Chapel Hill CRS
NOT_YET_RECRUITING

Chapel Hill, North Carolina, 27599-7215, United States
3203, Greensboro CRS
NOT_YET_RECRUITING

Greensboro, North Carolina, 27401, United States
3652, Vanderbilt Therapeutics (VT) CRS
NOT_YET_RECRUITING

Nashville, Tennessee, 37204, United States
5802, The Ponce de Leon Center CRS
RECRUITING

Atlanta, Georgia, 30308-2012, United States
601, University of California, Los Angeles CARE Center CRS
NOT_YET_RECRUITING

Los Angeles, California, 90035, United States
603, Harbor University of California Los Angeles Center CRS
NOT_YET_RECRUITING

Torrance, California, 90502, United States
6101, University of Colorado Hospital CRS
RECRUITING

Aurora, Colorado, 80045, United States
6201, Penn Therapeutics CRS
NOT_YET_RECRUITING

Philadelphia, Pennsylvania, 19104, United States
701, UCSD Antiviral Research Center CRS
NOT_YET_RECRUITING

San Diego, California, 92103, United States
7803, Weill Cornell Uptown CRS
NOT_YET_RECRUITING

New York, New York, 10065, United States
7804, Weill Cornell Chelsea CRS
NOT_YET_RECRUITING

New York, New York, 10010, United States
801, University of California, San Francisco HIV/AIDS CRS
NOT_YET_RECRUITING

San Francisco, California, 94110, United States

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