Can a liver drug help people with HIV? new trial aims to find out

NCT ID NCT07143968

Recruiting now Disease control Sponsor: Naga P. Chalasani Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This study tests whether resmetirom, a drug already approved for another liver condition, can safely reduce liver fat in people with HIV who also have fatty liver disease (MASLD). About 120 adults with well-controlled HIV will take either resmetirom or a placebo daily for 24 weeks. Researchers will measure changes in liver fat using MRI scans and track safety through blood tests and clinic visits.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: resmetirom
What this could lead to: If it works, this could point toward a treatment for fatty liver disease in people with HIV, a group often excluded from earlier studies.
What could go wrong: This is a small, early-phase trial (120 people) with a short 24-week treatment period. The drug may not reduce liver fat significantly, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

AIDS HIV infectious disease metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV (HUMAN IMMUNODEFICIENCY VIRUS) MASLD - METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE

Contacts and locations

Locations

Atlantic Clinical Research Institute
RECRUITING

West Palm Beach, Florida, 33409, United States
Duke University Medical Center
NOT_YET_RECRUITING

Durham, North Carolina, 27710, United States
Indiana University
RECRUITING

Indianapolis, Indiana, 46202, United States
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21205, United States
Mt Sinai Health System
NOT_YET_RECRUITING

New York, New York, 10029, United States
UC San Diego Altman Clinical and Translational Research Institute
NOT_YET_RECRUITING

La Jolla, California, 92037, United States
UT Health Houston
RECRUITING

Houston, Texas, 77030, United States
University of Alabama Birmingham
RECRUITING

Birmingham, Alabama, 35294, United States
University of California, San Francisco
NOT_YET_RECRUITING

San Francisco, California, 94143, United States
Virginia Commonwealth University
NOT_YET_RECRUITING

Richmond, Virginia, 23298, United States

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