Experimental HIV vaccine enters human testing – could it train the body to fight the virus?

NCT ID NCT06796686

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 1 trial tests a two-part HIV vaccine regimen in 42 healthy adults without HIV. The first shot primes the immune system, and later booster shots aim to mature antibody-producing cells. The main goal is to see if the regimen is safe and whether it triggers a specific immune response that could lead to broadly neutralizing antibodies against HIV.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HIV vaccine (426c.Mod.Core-C4b and HxB2.WT.Core-C4b with adjuvants 3M-052 AF and alum)
What this could lead to: If successful, this could point toward a vaccine that trains the immune system to make broadly neutralizing antibodies against HIV.
What could go wrong: This is a very early Phase 1 trial with only 42 healthy people. It primarily checks safety, not effectiveness. The vaccine may not produce the desired immune response or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV

Contacts and locations

Locations

Bridge HIV, San Francisco Department of Public Health
NOT_YET_RECRUITING

San Francisco, California, 94102, United States
Brigham and Women's Hospital Vaccine CRS (BWH VCRS)
RECRUITING

Boston, Massachusetts, 02115, United States
Columbia Physicians & Surgeons
NOT_YET_RECRUITING

New York, New York, 10032, United States
NY Blood Center CRS
WITHDRAWN

New York, New York, 10065, United States
Ponce de Leon Center CRS
NOT_YET_RECRUITING

Atlanta, Georgia, 30308, United States
The Hope Clinic of the Emory Vaccine Research Center; Emory University
RECRUITING

Decatur, Georgia, 30030, United States

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