Monthly HIV prevention pill could replace daily medication

NCT ID NCT07044297

Recruiting now Prevention Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

Summary

This study is testing whether a new monthly oral pill called MK-8527 works as well as or better than standard daily PrEP medication to prevent HIV infection. The trial will involve 4,390 HIV-negative adults at risk of HIV exposure. Researchers will compare how effective the monthly pill is at preventing HIV and monitor its safety compared to daily treatment.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

Bridge HIV - San Francisco Department of Public Health ( Site 0001)
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San Francisco, California, 94102, United States

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CELAN,S.A ( Site 1052)
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Guatemala City, 01010, Guatemala

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CEMDOE - Centro Médico de Diabetes, Obesidad y Especialidades ( Site 1001)
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Santo Domingo, Nacional, 10104, Dominican Republic

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Central Texas Clinical Research ( Site 0014)
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Austin, Texas, 78705, United States

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Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada ( Site 0352)
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CABA, Buenos Aires, C1425AGC, Argentina

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Centro de Estudios Infectológicos S.A. ( Site 0357)
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CABA, Buenos Aires, C1002ABN, Argentina

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Centro de Referência e Treinamento DST/AIDS ( Site 0400)
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São Paulo, São Paulo, 04121-000, Brazil

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Checkpoint Zurich ( Site 1100)
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Zurich, 8005, Switzerland

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Chulalongkorn Hospital ( Site 0807)
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Bangkok, Bangkok, 10330, Thailand

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Clinica de la Costa S.A.S. ( Site 0501)
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Barranquilla, Atlántico, 080020, Colombia

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Clínica Médica Especializada en Pediatría e Infectología Pediátrica - Dr. Mario Melgar ( Site 1051)
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Guatemala City, 01009, Guatemala

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Desmond Tutu Health Foundation ( Site 0250)
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Cape Town, Western Cape, 7925, South Africa

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Endocardio ( Site 1003)
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Santo Domingo, Nacional, 10147, Dominican Republic

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Faculty of Medicine Siriraj Hospital ( Site 0806)
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Bangkok, Bangkok, 10700, Thailand

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Foundation For Professional Development ( Site 0257)
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King Williams Town, Eastern Cape, 5660, South Africa

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Fred Hutchinson Cancer Center - The Seattle HIV Vaccine Trials Unit ( Site 0002)
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Seattle, Washington, 98104, United States

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Fundación Huésped ( Site 0350)
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CABA, Buenos Aires, C1427CEA, Argentina

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Fundación IDEAA ( Site 0351)
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Buenos Aires, C1405CKC, Argentina

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Fundación Valle del Lili ( Site 0502)
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Cali, Valle del Cauca Department, 760036, Colombia

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Fundaçao de Medicina Tropical Doutor Heitor Vieira Dourado ( Site 0412)
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Manaus, Amazonas, 69040-000, Brazil

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HIV Netherlands Australia Thailand Research Collaboration ( Site 0808)
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Bangkok, Bangkok, 10330, Thailand

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Hope Clinic of the Emory Vaccine Center ( Site 0009)
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Decatur, Georgia, 30030, United States

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Hopital Bichat - Claude Bernard ( Site 0101)
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Paris, Île-de-France Region, 75018, France

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Hopital Saint Louis ( Site 0100)
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Paris, 75010, France

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Hospital Dr. Hernán Henríquez Aravena ( Site 0451)
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Temuco, Región de la Araucanía, 4781151, Chile

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Hospital Geral de Nova Iguacu ( Site 0411)
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Nova Iguaçu, Rio de Janeiro, 26030-380, Brazil

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Hospital Universitario San Ignacio ( Site 0503)
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Bogotá, Bogota D.C., 110231, Colombia

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Hospital das Clinicas FMUSP ( Site 0401)
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São Paulo, São Paulo, 05403-000, Brazil

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Hôpital Tenon ( Site 0102)
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Paris, 75020, France

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IPS SURA San Diego ( Site 0500)
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Medellín, Antioquia, 50016, Colombia

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Inselspital Bern ( Site 1103)
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Bern, Canton of Bern, 3010, Switzerland

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Institute of HIV Research and Innovation ( Site 0810)
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Bangkok, Bangkok, 10330, Thailand

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Instituto Dermatológico y Cirugía de Piel "Dr. Huberto Bogaert Díaz" ( Site 1002)
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Santo Domingo de Guzman, Santo Domingo Province, 10305, Dominican Republic

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Instituto Nacional de Infectologia Evandro Chagas ( Site 0407)
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Rio de Janeiro, 21040-360, Brazil

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Instituto de Investigaciones Clínicas Mar del Plata ( Site 0353)
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Mar del Plata, Buenos Aires, B7600FZO, Argentina

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Investigaciones Medicas en Salud ( Site 0552)
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Lima, 15046, Peru

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MEDI-K ( Site 1053)
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Guatemala City, 01009, Guatemala

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Meharry Medical College ( Site 0013)
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Nashville, Tennessee, 37208, United States

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Montefiore Medical Center ( Site 0017)
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The Bronx, New York, 10467, United States

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NC TraCS Institute - CTRC; University of North Carolina at Chapel Hill ( Site 0008)
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Chapel Hill, North Carolina, 27514-7064, United States

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Obras Sociais Irma Dulce ( Site 0406)
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Salvador, Estado de Bahia, 41680-430, Brazil

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Open Arms Healthcare Center ( Site 0025)
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Jackson, Mississippi, 39202, United States

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Orlando Immunology Center ( Site 0021)
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Orlando, Florida, 32803, United States

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Perinatal HIV Research Unit (PHRU) ( Site 0253)
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Soweto, Gauteng, 1864, South Africa

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Philadelphia Fight Community Health Centers ( Site 0011)
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Philadelphia, Pennsylvania, 19107, United States

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Policlínico Socios en Salud ( Site 0557)
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Lima, 15024, Peru

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Prisma Health Richland Hospital-Clinical Research Unit ( Site 0007)
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Columbia, South Carolina, 29203, United States

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Regional Center for Infectious Diseases ( Site 0018)
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Greensboro, North Carolina, 27401, United States

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Research Institute for Health Sciences ( Site 0809)
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Muang, Chiang Mai, 50200, Thailand

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Ricardo Diaz Scientific Solutions ( Site 0402)
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São Paulo, São Paulo, 04030-030, Brazil

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Rutgers New Jersey Medical School ( Site 0010)
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Newark, New Jersey, 07103, United States

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Saint Hope Foundation, Inc. ( Site 0015)
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Bellaire, Texas, 77401, United States

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School of Medicine Federal University of Minas Gerais ( Site 0417)
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Belo Horizonte, Minas Gerais, 30130-100, Brazil

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Setshaba Research Centre ( Site 0252)
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Pretoria, Gauteng, 0152, South Africa

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St. Jude Children's Research Hospital ( Site 0026)
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Memphis, Tennessee, 38105, United States

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UCLA Center for Clinical AIDS Research and Education ( Site 0004)
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Los Angeles, California, 90035, United States

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USA Health University Hospitals ( Site 0020)
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Mobile, Alabama, 36617, United States

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Universidad San Sebastian - Providencia ( Site 0454)
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Santiago, Region M. de Santiago, 7500000, Chile

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Universidad de Chile - Hospital Clínico Universidad de Chile-Inmunologia Alergia y VIH ( Site 0450)
RECRUITING

Santiago, Region M. de Santiago, 8380420, Chile

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Universiti Malaya Medical Centre ( Site 0651)
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Kuala Lumpur, 50603, Malaysia

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University Hospital Basel ( Site 1102)
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Basel, Canton of Basel-City, 4031, Switzerland

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University Medical Center New Orleans ( Site 0024)
RECRUITING

New Orleans, Louisiana, 70112, United States

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University of Alabama at Birmingham-UAB 1917 Research Clinic ( Site 0006)
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Birmingham, Alabama, 35222, United States

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University of Illinois Chicago ( Site 0027)
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Chicago, Illinois, 60612, United States

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University of Miami RAPID Research ( Site 0003)
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Miami, Florida, 33136, United States

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University of Pittsburgh Medical Center-Division of Infectious Diseases ( Site 0022)
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Pittsburgh, Pennsylvania, 15213, United States

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Via Libre ( Site 0551)
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Lima, 15001, Peru

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Whitman-Walker Institute ( Site 0016)
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Washington D.C., District of Columbia, 20032, United States

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Wits Maternal Adolescent and Child Health Research Unit (WMRU) ( Site 0256)
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Durban, KwaZulu-Natal, 4001, South Africa

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Wits RHI Research Center ( Site 0251)
RECRUITING

Johannesburg, Gauteng, 2001, South Africa

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Conditions

Explore the condition pages connected to this study.

HIV PRE-EXPOSURE PROPHYLAXIS HUMAN IMMUNODEFICIENCY VIRUS (HIV)