Monthly HIV prevention pill could replace daily dose
NCT ID NCT07044297
First seen Jun 26, 2026 · Last updated Aug 14, 2026 · Updated 13 times
Summary
This large phase 3 trial is testing whether a new oral pill called MK-8527, taken just once a month, can prevent HIV infection as well as the standard daily PrEP pill. About 4,390 people at risk of HIV will be randomly assigned to receive either the monthly pill or daily Truvada (plus placebos to maintain blinding). The study will track new HIV infections and side effects over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- MK-8527 (oral tablet taken once a month)
- What this could lead to
- If successful, this could offer a convenient once-monthly pill for HIV prevention, potentially improving adherence and reducing daily pill burden.
- What could go wrong
- This is a phase 3 trial, but results are not yet known. The monthly pill may not be as effective as daily PrEP, and side effects or tolerability issues could arise.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
Locations
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Asian Hospital and Medical Center ( Site 0704)
ACTIVE_NOT_RECRUITINGMuntinlupa, National Capital Region, 1780, Philippines
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Asociación Civil Impacta Salud y Educación ( Site 0553)
ACTIVE_NOT_RECRUITINGLima, 15063, Peru
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Asociación Civil Selva Amazónica ( Site 0556)
RECRUITINGIquitos, Loreto, 16001, Peru
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Bridge HIV - San Francisco Department of Public Health ( Site 0001)
RECRUITINGSan Francisco, California, 94102, United States
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CELAN,S.A ( Site 1052)
RECRUITINGGuatemala City, 01010, Guatemala
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CEMDOE - Centro Médico de Diabetes, Obesidad y Especialidades ( Site 1001)
ACTIVE_NOT_RECRUITINGSanto Domingo, Nacional, 10104, Dominican Republic
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Central Texas Clinical Research ( Site 0014)
RECRUITINGAustin, Texas, 78705, United States
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Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada ( Site 0352)
ACTIVE_NOT_RECRUITINGCABA, Buenos Aires, C1425AGC, Argentina
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Centro de Estudios Infectológicos S.A. ( Site 0357)
ACTIVE_NOT_RECRUITINGCABA, Buenos Aires, C1002ABN, Argentina
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Centro de Referência e Treinamento DST/AIDS ( Site 0400)
ACTIVE_NOT_RECRUITINGSão Paulo, São Paulo, 04121-000, Brazil
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Checkpoint Zurich ( Site 1100)
RECRUITINGZurich, 8005, Switzerland
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Chulalongkorn Hospital ( Site 0807)
RECRUITINGBangkok, Bangkok, 10330, Thailand
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Clinica de la Costa S.A.S. ( Site 0501)
RECRUITINGBarranquilla, Atlántico, 080020, Colombia
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Clínica Médica Especializada en Pediatría e Infectología Pediátrica - Dr. Mario Melgar ( Site 1051)
ACTIVE_NOT_RECRUITINGGuatemala City, 01009, Guatemala
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Desmond Tutu Health Foundation ( Site 0250)
RECRUITINGCape Town, Western Cape, 7925, South Africa
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Endocardio ( Site 1003)
ACTIVE_NOT_RECRUITINGSanto Domingo, Nacional, 10147, Dominican Republic
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Faculty of Medicine Siriraj Hospital ( Site 0806)
ACTIVE_NOT_RECRUITINGBangkok, Bangkok, 10700, Thailand
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Foundation For Professional Development ( Site 0257)
ACTIVE_NOT_RECRUITINGKing Williams Town, Eastern Cape, 5660, South Africa
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Fred Hutchinson Cancer Center - The Seattle HIV Vaccine Trials Unit ( Site 0002)
RECRUITINGSeattle, Washington, 98104, United States
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Fundación Huésped ( Site 0350)
ACTIVE_NOT_RECRUITINGCABA, Buenos Aires, C1427CEA, Argentina
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Fundación IDEAA ( Site 0351)
ACTIVE_NOT_RECRUITINGBuenos Aires, C1405CKC, Argentina
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Fundación Valle del Lili ( Site 0502)
ACTIVE_NOT_RECRUITINGCali, Valle del Cauca Department, 760032, Colombia
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Fundaçao de Medicina Tropical Doutor Heitor Vieira Dourado ( Site 0412)
ACTIVE_NOT_RECRUITINGManaus, Amazonas, 69040-000, Brazil
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HIV Netherlands Australia Thailand Research Collaboration ( Site 0808)
RECRUITINGBangkok, Bangkok, 10330, Thailand
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Hanoi Medical University Hospital ( Site 0851)
ACTIVE_NOT_RECRUITINGHanoi, Hanoi, 100000, Vietnam
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Hope Clinic of the Emory Vaccine Center ( Site 0009)
RECRUITINGDecatur, Georgia, 30030, United States
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Hopital Bichat - Claude Bernard ( Site 0101)
ACTIVE_NOT_RECRUITINGParis, Île-de-France Region, 75018, France
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Hopital Saint Louis ( Site 0100)
ACTIVE_NOT_RECRUITINGParis, 75010, France
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Hospital Dr. Hernán Henríquez Aravena ( Site 0451)
ACTIVE_NOT_RECRUITINGTemuco, Araucania, 4781151, Chile
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Hospital Geral de Nova Iguacu ( Site 0411)
ACTIVE_NOT_RECRUITINGNova Iguaçu, Rio de Janeiro, 26030-380, Brazil
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Hospital Universitario San Ignacio ( Site 0503)
ACTIVE_NOT_RECRUITINGBogotá, Bogota D.C., 110231, Colombia
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Hospital das Clinicas FMUSP ( Site 0401)
ACTIVE_NOT_RECRUITINGSão Paulo, São Paulo, 05403-000, Brazil
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Hôpital Tenon ( Site 0102)
ACTIVE_NOT_RECRUITINGParis, 75970, France
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IPS SURA San Diego ( Site 0500)
RECRUITINGMedellín, Antioquia, 50016, Colombia
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Impact Research and Development Organisation (IRDO) ( Site 0202)
RECRUITINGKisumu, 40141, Kenya
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Inselspital Bern ( Site 1103)
RECRUITINGBern, Canton of Bern, 3010, Switzerland
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Institute of HIV Research and Innovation ( Site 0810)
RECRUITINGBangkok, Bangkok, 10330, Thailand
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Instituto Dermatológico y Cirugía de Piel "Dr. Huberto Bogaert Díaz" ( Site 1002)
ACTIVE_NOT_RECRUITINGSanto Domingo de Guzman, Santo Domingo Province, 10306, Dominican Republic
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Instituto Nacional de Infectologia Evandro Chagas ( Site 0407)
ACTIVE_NOT_RECRUITINGRio de Janeiro, 21040-360, Brazil
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Instituto de Investigaciones Clínicas Mar del Plata ( Site 0353)
ACTIVE_NOT_RECRUITINGMar del Plata, Buenos Aires, B7600FZO, Argentina
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Investigaciones Medicas en Salud ( Site 0552)
ACTIVE_NOT_RECRUITINGLima, 15046, Peru
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LoveYourself Inc. ( Site 0705)
ACTIVE_NOT_RECRUITINGMandaluyong, National Capital Region, 1552, Philippines
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MEDI-K ( Site 1053)
ACTIVE_NOT_RECRUITINGGuatemala City, 01009, Guatemala
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Meharry Medical College ( Site 0013)
RECRUITINGNashville, Tennessee, 37208, United States
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Montefiore Medical Center ( Site 0017)
RECRUITINGThe Bronx, New York, 10467, United States
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NC TraCS Institute - CTRC; University of North Carolina at Chapel Hill ( Site 0008)
RECRUITINGChapel Hill, North Carolina, 27514-7064, United States
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Nyanza Reproductive Health Society ( Site 0200)
RECRUITINGKisumu, 40100, Kenya
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Obras Sociais Irma Dulce ( Site 0406)
ACTIVE_NOT_RECRUITINGSalvador, Estado de Bahia, 41680-430, Brazil
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Open Arms Healthcare Center ( Site 0025)
RECRUITINGJackson, Mississippi, 39202, United States
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Orlando Immunology Center ( Site 0021)
RECRUITINGOrlando, Florida, 32803, United States
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Partners for Health and Development in Africa ( Site 0201)
RECRUITINGNairobi, Nairobi City, 00506, Kenya
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Perinatal HIV Research Unit (PHRU) ( Site 0253)
RECRUITINGSoweto, Gauteng, 1864, South Africa
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Philadelphia Fight Community Health Centers ( Site 0011)
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
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Philippine General Hospital ( Site 0700)
ACTIVE_NOT_RECRUITINGManila, National Capital Region, 1000, Philippines
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Policlínico Socios en Salud ( Site 0557)
ACTIVE_NOT_RECRUITINGLima, 15024, Peru
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Prisma Health Richland Hospital-Clinical Research Unit ( Site 0007)
RECRUITINGColumbia, South Carolina, 29203, United States
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Regional Center for Infectious Diseases ( Site 0018)
RECRUITINGGreensboro, North Carolina, 27401, United States
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Research Institute for Health Sciences ( Site 0809)
RECRUITINGMuang, Chiang Mai, 50200, Thailand
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Ricardo Diaz Scientific Solutions ( Site 0402)
ACTIVE_NOT_RECRUITINGSão Paulo, São Paulo, 04030-030, Brazil
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Rutgers New Jersey Medical School ( Site 0010)
RECRUITINGNewark, New Jersey, 07103, United States
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Saint Hope Foundation, Inc. ( Site 0015)
RECRUITINGBellaire, Texas, 77401, United States
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School of Medicine Federal University of Minas Gerais ( Site 0417)
RECRUITINGBelo Horizonte, Minas Gerais, 30130-100, Brazil
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Setshaba Research Centre ( Site 0252)
ACTIVE_NOT_RECRUITINGPretoria, Gauteng, 0152, South Africa
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St. Jude Children's Research Hospital ( Site 0026)
RECRUITINGMemphis, Tennessee, 38105, United States
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Thu Duc General Hospital ( Site 0881)
ACTIVE_NOT_RECRUITINGHo Chi Minh City, 700000, Vietnam
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UCLA Center for Clinical AIDS Research and Education ( Site 0004)
RECRUITINGLos Angeles, California, 90035, United States
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USA Health University Hospitals ( Site 0020)
RECRUITINGMobile, Alabama, 36617, United States
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Universidad Nacional Mayor De San Marcos ( Site 0555)
ACTIVE_NOT_RECRUITINGLima, 15081, Peru
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Universidad San Sebastian - Providencia ( Site 0454)
ACTIVE_NOT_RECRUITINGSantiago, Region M. de Santiago, 7500000, Chile
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Universidad de Chile - Hospital Clínico Universidad de Chile-Inmunologia Alergia y VIH ( Site 0450)
ACTIVE_NOT_RECRUITINGSantiago, Region M. de Santiago, 8380420, Chile
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Universiti Malaya Medical Centre ( Site 0651)
ACTIVE_NOT_RECRUITINGKuala Lumpur, 50603, Malaysia
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University Hospital Basel ( Site 1102)
RECRUITINGBasel, Canton of Basel-City, 4031, Switzerland
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University Medical Center New Orleans ( Site 0024)
RECRUITINGNew Orleans, Louisiana, 70112, United States
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University of Alabama at Birmingham-UAB 1917 Research Clinic ( Site 0006)
RECRUITINGBirmingham, Alabama, 35222, United States
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University of Illinois Chicago ( Site 0027)
RECRUITINGChicago, Illinois, 60612, United States
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University of Miami RAPID Research ( Site 0003)
RECRUITINGMiami, Florida, 33136, United States
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University of Pittsburgh Medical Center-Division of Infectious Diseases ( Site 0022)
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
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Via Libre ( Site 0551)
ACTIVE_NOT_RECRUITINGLima, 15001, Peru
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Whitman-Walker Institute ( Site 0016)
RECRUITINGWashington D.C., District of Columbia, 20032, United States
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Wits Maternal Adolescent and Child Health Research Unit (WMRU) ( Site 0256)
ACTIVE_NOT_RECRUITINGDurban, KwaZulu-Natal, 4001, South Africa
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Wits RHI Research Center ( Site 0251)
RECRUITINGJohannesburg, Gauteng, 2001, South Africa
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