Can HIIT or moderate exercise improve sleep for people with HIV?

NCT ID NCT04946994

Completed Knowledge-focused Sponsor: Christine Horvat Davey Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how two types of exercise—high-intensity interval training (HIIT) and continuous moderate exercise—affect sleep and inflammation in 52 older adults with HIV. Participants exercised three times a week for 16 weeks. Researchers measured sleep quality through surveys and wrist devices, and checked blood for inflammation markers. The goal was to see if HIIT leads to better sleep and lower inflammation than moderate exercise.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: exercise (high-intensity interval training and continuous moderate-intensity exercise)
What this could lead to: If successful, this study could show that specific exercise programs improve sleep and reduce inflammation in older adults with HIV, pointing toward better health strategies.
What could go wrong: This is a small, completed study with only 52 participants, so results may not apply to everyone. It also relies on self-reported sleep quality, which can be subjective.

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Conditions

The condition(s) this trial relates to.

AIDS HIV infectious disease sleep disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV SLEEP

Contacts and locations

Locations

Case Western Reserve University

Cleveland, Ohio, 44106, United States
University if Washington

Seattle, Washington, 98195, United States
University of Colorado

Aurora, Colorado, 80045, United States

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