Herpesviridae infectious disease

This early-stage trial tests a vaccine called OSU-2131, designed to help the immune system fight Epstein-Barr virus (EBV). EBV can cause cancers in people who have weakened immune systems, such as those awaiting organ transplants. The study includes healthy volunteers and transpl…

This phase 2 trial tests a CMV vaccine (CMV-MVA Triplex) given before a liver transplant to see if it reduces the need for antiviral drugs after surgery. The study enrolls 416 CMV-negative adults awaiting a liver transplant from a CMV-positive donor. Participants receive two vacc…

This study tests the Shingrix vaccine in people with HIV and healthy volunteers to see how well it boosts immunity against shingles. Participants receive two shots two months apart and are followed for a year. The goal is to understand if the vaccine works safely in those with di…

This early-stage study is testing two new vaccines (V350A and V350B) designed to prevent diseases caused by the Epstein-Barr virus (EBV), which can cause infectious mononucleosis and is linked to certain cancers and multiple sclerosis. The study will enroll 250 healthy adults and…

This study tests a new chickenpox vaccine in 600 healthy toddlers aged 12-15 months. The children receive two doses, and the new vaccine is compared to the current standard, Varivax. The goal is to see if the new vaccine produces a strong immune response and is safe.

This study tests a new chickenpox vaccine in 750 healthy children aged 12-15 months. Researchers will compare its safety to the existing Varivax vaccine. The goal is to see if the new vaccine causes similar side effects like injection site pain, fever, or rash.

This study tests a new chickenpox vaccine given as a muscle injection in healthy children aged 12 to 15 months. It compares the immune response and safety of this vaccine to the standard shot given under the skin. The study also looks at combining it with the MMR vaccine. About 9…

This study tests a new chickenpox vaccine in healthy children aged 12 to 15 months who have never had chickenpox or the vaccine. Researchers want to see if the new vaccine works as well as the approved Varivax vaccine and if different batches of the new vaccine produce consistent…

This study tests two experimental vaccines against Epstein-Barr virus (EBV), which causes mono and is linked to cancers. Researchers will give 750 healthy adults aged 18-29 three shots over several months to check for side effects and immune response. The goal is to find a safe v…

This study tests a new chickenpox vaccine called MG1111 in healthy children aged 1 to 12 years. About 474 kids will receive either the new vaccine or the current one (Varivax) to compare safety and immune response. Participants will be followed for 42 days after each dose, and up…

This study looks at how well the shingles vaccine (Shingrix) works in adults with kidney failure who are waiting for a kidney transplant. Researchers want to see if giving an extra dose after the transplant boosts the immune response. About 132 participants will be followed for u…

This study tests the shingles vaccine (SHINGRIX) in 160 people: transplant recipients on different immunosuppressant drugs and their healthy housemates. Researchers will measure immune responses at five time points over a year to see if the vaccine works well in these groups. The…

This early-stage trial is testing an mRNA vaccine called mRNA-1189 to see if it is safe and triggers an immune response against Epstein-Barr virus (EBV). EBV is a common virus that can cause mononucleosis and is linked to certain cancers. The study involves 120 healthy adults age…

This study looks at how well a second dose of the chickenpox vaccine works and if it is safe for healthy children aged 15 months to 12 years. About 300 children who already had one dose at 12 months old will get a second dose made by Sinovac. Researchers will measure antibody lev…

This study is testing a new shingles vaccine (PED-HZ/su) in children aged 1 to 17 who have had a kidney transplant and have weakened immune systems. The vaccine is given as two shots in the arm. Researchers are checking how safe it is, what side effects occur, and how well it boo…

This study is testing a new mRNA vaccine to prevent shingles (herpes zoster) in adults aged 40 and older. The vaccine uses mRNA technology, similar to some COVID-19 vaccines, and is freeze-dried for easier storage. Researchers will compare different doses against existing vaccine…

This study looks at how well the shingles vaccine Shingrix works in people who have had a stem cell transplant. About 55 adults who received the vaccine at least a year after their transplant will have their immune responses measured. Researchers want to see if the timing of the …

This study tests a new recombinant shingles vaccine in healthy adults aged 40 and above. Researchers will give two doses and monitor for side effects and immune response. The trial involves 645 participants and compares the new vaccine to an existing one (Shingrix) and placebo.

This phase 2 trial tests whether the drug nivolumab can slow or stop the growth of Epstein-Barr virus (EBV)-positive lymphoproliferative disorders and non-Hodgkin lymphomas. About 40 people aged 12 and older whose cancers have not responded to standard therapy will receive nivolu…

This study tests a new treatment called LB-DTK-CMV for people with cytomegalovirus (CMV) retinitis that has not responded to standard antiviral medicines. The treatment uses a patient's own immune cells, specially trained to attack CMV, and is given as two infusions. The trial ai…

This study tests a drug called felzartamab in people who received a kidney transplant and later developed microvascular inflammation (MVI), a type of injury to small blood vessels in the new kidney that can lead to serious problems. The trial includes 81 participants who will rec…

This study looks at a newly recognized disease called KSHV Inflammatory Cytokine Syndrome (KICS), caused by a virus that can also lead to certain cancers. Researchers aim to learn more about the disease and test experimental treatments, including antiviral and chemotherapy drugs,…

This early-stage trial tests whether adding the drug pomalidomide to standard chemotherapy (with or without rituximab) is safe and effective for people with HIV who have aggressive B-cell non-Hodgkin lymphoma. About 25 adults with high-risk features will receive up to 6 cycles of…

This early-phase trial tests a treatment called LB-DTK-MV, which uses immune cells from a healthy donor to fight three viruses (CMV, BKV, and EBV) that have become resistant to standard antiviral drugs. The study includes 27 adults who have had a stem cell transplant or certain c…

This early-phase trial tests a new type of immune cell therapy for patients with EBV-positive Hodgkin or non-Hodgkin lymphoma that has returned or not responded to standard treatments. The researchers add a gene called C7R to the patient's own T cells to help them survive longer …

This study tests whether giving patients special donor immune cells (called CD45RA-depleted DLI) can treat viral infections that persist after a stem cell transplant. The trial involves 30 participants who have not improved with standard antiviral drugs. Researchers will measure …

This early-phase trial is testing an oral drug called VK-2019 in 30 adults with a type of lymphoma (DLBCL) that is linked to the Epstein-Barr virus and has not responded to at least two prior treatments. Participants take the drug daily in 28-day cycles at one of three dose level…

This trial investigates whether specially grown immune cells, called pathogen-specific cytotoxic T lymphocytes (CTLs), can safely and effectively treat stubborn infections like EBV, CMV, and adenovirus in people with weakened immune systems, such as stem cell or organ transplant …

This study looks at whether people with a type of throat cancer linked to the Epstein-Barr virus can safely receive lower doses of radiation after initial chemotherapy. The goal is to see if reducing radiation can still control the cancer while causing fewer long-term side effect…

This study looks at whether stem cell transplant patients can safely stop taking a medicine called letermovir earlier if their immune system shows a strong response to CMV. About 105 participants will be monitored to see if this approach reduces infections and side effects compar…

This early-phase study tests whether specially trained immune cells from healthy donors can safely treat viral infections (EBV, CMV, adenovirus, BK virus) in patients who have had a stem cell transplant or certain CAR-T therapy. These infections can be life-threatening when the i…

This study tests whether the drug letermovir can prevent cytomegalovirus (CMV) from coming back in kidney or kidney/pancreas transplant patients who are at high risk. About 90 adults will take letermovir daily for 84 days and be followed for 6 months. The goal is to see if it red…

This study is testing the drug letermovir to prevent cytomegalovirus (CMV) infection in children and teens who have had a kidney transplant and weigh less than 40 kg. About 40 participants will receive the drug to see how it moves through their bodies and if it is safe. The goal …

This early-stage trial tests whether specially grown immune cells from a donor can safely help transplant patients fight off viral infections that standard treatments can't control. The cells target Epstein-Barr virus, cytomegalovirus, adenovirus, and BK virus. Up to 36 adults wh…

This study follows about 10 adults and children (12 years and older) in Argentina who have a CMV infection after an organ transplant that did not get better with standard treatments. Researchers will track how well maribavir works and what side effects occur during routine care. …

This study tests whether a drug called letermovir is easier to tolerate than the standard treatment for preventing CMV infection in heart and lung transplant recipients. About 80 adults who have had a heart or lung transplant will take either letermovir or the usual drug, and res…

This study tests a drug called maribavir for children and teens who have a CMV infection after a stem cell or organ transplant. About 80 participants will take the drug for 8 weeks and be followed for 12 more weeks. The goal is to find the safest dose and see how well it controls…

This early-phase study tests an oral antiviral drug called letermovir in 12 infants born with symptomatic congenital cytomegalovirus (CMV) infection. The goal is to find the right dose and see if it safely lowers the amount of virus in the body. Babies also receive standard treat…

This phase 3 trial tests tabelecleucel, a cell therapy made from donor immune cells, in 115 organ or stem cell transplant patients who developed a rare cancer (EBV+ PTLD) after standard treatment failed. The goal is to see if it can shrink tumors and improve outcomes. Participant…

This study tests whether adding the malaria drug artesunate to standard antiviral treatment can better control cytomegalovirus (CMV) infection in people who have received a solid organ transplant (kidney, lung, heart, or liver). About 90 adult participants will receive either a l…

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …

This study tests whether the antiviral drug letermovir can prevent cytomegalovirus (CMV) infection in children and teens who have had a stem cell transplant. About 105 participants aged 2 to 17 will receive letermovir and be monitored for 14 weeks. The goal is to see if the drug …

This study tests whether using early drug monitoring and a dose-adjustment calculator can help infants under 90 days old with sepsis reach target vancomycin levels more quickly. Currently, doctors must wait 24-48 hours to check drug levels, which can delay effective treatment. Th…

This early study tests whether immune cells from a donor can safely fight cytomegalovirus (CMV) or adenovirus (AdV) infections in people who have had a stem cell or solid organ transplant. About 20 participants will receive these virus-specific T-cells intravenously. The main goa…

This early-stage trial is testing whether genetically modified T-cells can safely control viral infections in cancer patients with weakened immune systems. The T-cells are designed to target specific viruses like CMV, BK virus, or COVID-19. The study involves 30 participants and …

This study tests whether a web app that customizes the dose of the antiviral drug ganciclovir can clear cytomegalovirus (CMV) faster in 232 children with weakened immune systems. Participants are recruited from seven hospitals in Australia and New Zealand. The goal is to see if p…

This phase II trial is testing whether an anti-viral drug called valganciclovir (Valcyte) can help treat breast cancer that has spread to the brain. The study includes 28 adults with progressive brain metastases who also have evidence of a common virus called CMV. Participants ta…

This study looks at the best length of treatment with the drug maribavir for a hard-to-treat CMV infection that can happen after a stem cell transplant. About 218 adults who have already had a transplant and have this infection will be randomly assigned to different treatment dur…

This early-phase trial tests whether specially engineered immune cells (EBV-TCR-T cells) can safely control Epstein-Barr virus infections in people who have had a stem cell transplant. About 12 participants will receive one to three infusions of donor-derived cells. The main goal…

This study tests whether the drug letermovir can stop cytomegalovirus (CMV) in unborn babies better than the current treatment valaciclovir. Pregnant women with a CMV-infected fetus will take one of the two drugs daily until delivery. The goal is to see if letermovir leads to a n…

This study tests whether adding special immune cells from the mother to standard antiviral medicine can safely and more effectively treat moderate to severe CMV infection in newborns. Babies up to 21 days old with confirmed CMV disease may join. All receive antiviral drugs, and s…

This study looks at whether monitoring the immune response to the cytomegalovirus (CMV) can help prevent CMV disease in people who receive a lung transplant. About 100 adult lung transplant patients who have had CMV in the past will be followed. The goal is to see if tracking CMV…

This study tests whether giving patients donor-derived immune cells (VSTs) on a regular schedule can prevent dangerous viral infections after a stem cell transplant. 180 participants will be randomly assigned to receive VSTs either on a fixed schedule or only when a virus is dete…

This study tests a drug called maribavir in Chinese adults who had a stem cell or organ transplant and have a CMV infection that did not get better with standard treatments. The main goal is to see if maribavir is safe and well-tolerated. Researchers will also check if the drug c…

This study tests whether specially selected immune cells from a donor can safely treat cytomegalovirus (CMV) and adenovirus (ADV) infections in children who have had a stem cell transplant. About 42 participants will receive these virus-fighting cells and be monitored for viral l…

This study compares two ways to prevent cytomegalovirus (CMV) infection in kidney transplant patients who already carry the virus. One approach gives antiviral drugs to everyone for 3 months, while the other uses immune system tests to decide who needs treatment. The goal is to s…

This study tests whether adding letermovir to standard antiviral treatment helps clear cytomegalovirus (CMV) infection faster in people who have received a lung transplant. About 40 participants will receive either letermovir or a placebo alongside their usual medication for 21 d…

This study compares two ways of giving the antibiotic cefepime to very sick patients with sepsis in the ICU. The new method adjusts the dose based on the patient's kidney function, using only standard doses. The main goal is to see if this approach is easy for doctors to use and …

This study tests whether combining two drugs, golidocitinib and selinexor, can control chronic active Epstein-Barr virus disease (CAEBVD). Researchers will enroll 28 adults with CAEBVD and track how well the treatment reduces symptoms and lowers virus levels in the blood. It is a…

This early-phase study tests a new treatment for Epstein-Barr virus (EBV) that can occur after a stem cell transplant. The treatment uses specially engineered immune cells (EBV-TCR-T cells) to find and destroy virus-infected cells. Up to 18 adult patients who have persistent EBV …

This study tests whether the drug letermovir can prevent cytomegalovirus (CMV) from reactivating in people who have received a type of CAR T-cell therapy called axicabtagene ciloleucel. CMV is a common virus that can cause serious illness when the immune system is weakened. The t…

This study tests whether injecting anti-VEGF medication directly into the cornea can safely reduce abnormal blood vessel growth caused by herpes simplex keratitis. One hundred adults will receive either the injection plus antiviral eye drops or standard antiviral drops alone. Res…

This clinical trial compares two drugs for shingles (herpes zoster): brivudine and famciclovir. The study will enroll 140 adults with acute shingles to see which drug better reduces pain and speeds up healing. Researchers will track pain levels for up to 90 days and monitor for l…

This study tests whether adding letermovir to the standard drug valganciclovir works better than valganciclovir alone for treating CMV infections in kidney transplant recipients. About 80 adults who have a kidney transplant and a CMV infection will take part. The goal is to see i…

This study tests whether giving CytoGam® (CMV immunoglobulin) after standard antiviral treatment can prevent late CMV infection in high-risk kidney or liver transplant recipients. About 80 participants who are CMV-negative but receive an organ from a CMV-positive donor will be en…

This study tests if valacyclovir works as well as valganciclovir to prevent CMV and EBV infections in kidney transplant patients. Valganciclovir can cause bone marrow suppression, a serious side effect. The study will enroll 80 kidney transplant recipients and monitor them for ne…

This study tests whether specially grown immune cells from an unrelated donor can safely treat viral infections in people with weakened immune systems, such as after a stem cell transplant. About 750 participants will receive these cells and be monitored for side effects like inf…

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This study tests whether giving zinc supplements along with standard antibiotics can reduce deaths and improve recovery in young infants (0-59 days old) hospitalized with severe infections like sepsis or pneumonia. About 3,250 babies in Tanzania will receive either zinc or a plac…

This study tests whether the drug maribavir can safely control cytomegalovirus (CMV) infections in people with multiple myeloma or lymphoma who are receiving bispecific antibody therapy. About 20 adults will take maribavir, and researchers will measure how well it lowers CMV leve…

This study is testing whether the antiviral drug letermovir can prevent a common and serious viral infection called CMV in people with relapsed/refractory multiple myeloma who are receiving the immunotherapy elranatamab. The trial will enroll 40 adults who are CMV-positive. Resea…

This study tests whether the antiviral drug acyclovir helps people on breathing machines who have pneumonia and also have herpes simplex virus (HSV) in their lungs. About 616 adults in intensive care will be randomly assigned to receive acyclovir or no antiviral treatment. The go…

This study follows 168 adults in South Korea who have had a transplant and developed a CMV infection that didn't respond to other treatments. They will take LIVTENCITY (Maribavir) as part of routine care, and researchers will track side effects and how well the drug clears the vi…

This study is testing whether a drug called Cytogam (CMVIG) can prevent cytomegalovirus (CMV) infection in kidney transplant patients who are switching to a new immunosuppressant. The researchers will measure antibody levels in 30 adult patients over 8 weeks to see how the drug w…

This study tests an experimental therapy that uses special immune cells (T-cells) from a donor to fight cytomegalovirus (CMV) infection in people who have had a stem cell transplant. The therapy aims to boost the patient's immune system to clear the infection. About 20 participan…

This study tests a vaccine called CMV-MVA Triplex in 80 children who have had a stem cell transplant and are at risk for CMV infection. The goal is to find the best dose and see if it safely prevents CMV reactivation. Participants receive the vaccine and are monitored for side ef…

This study in Japan tracks 250 organ or stem cell transplant patients whose CMV infection did not improve with standard treatments. Participants take Maribavir tablets as part of their regular care, and doctors monitor side effects and whether the virus clears from the blood for …

This study tests whether a newer drug, letermovir, is safer and more effective than the standard valganciclovir for preventing CMV infection in heart transplant recipients. About 150 moderate- to high-risk adults will be enrolled. The main focus is on reducing side effects like l…

This study follows 75 adults who have had a stem cell or solid organ transplant and are being treated with maribavir for cytomegalovirus (CMV) infection. Researchers will track how well the drug clears the virus, how long treatment lasts, and any side effects. The goal is to see …

This study looks at 200 adults with inflammatory bowel disease (IBD) who are hospitalized due to worsening symptoms. Researchers want to see if testing blood or stool for CMV (a common virus) is as accurate as the standard method of testing a tissue sample from the colon. The goa…

This study tests a decision-support tool called MyCMV that helps doctors interpret blood test results for cytomegalovirus (CMV) infection during pregnancy. CMV is a common virus that can cause hearing loss and developmental problems in babies if the mother catches it for the firs…

This early-phase trial tests a vaccine (CMV-MVA Triplex) given to both stem cell donors and recipients to boost immunity against cytomegalovirus (CMV) and prevent active infection after a half-matched stem cell transplant. About 46 people with various blood cancers will take part…

This study tests a personalized approach to stopping the drug Letermovir, which prevents a common virus called CMV after a stem cell transplant. Instead of giving the drug for a fixed 100 days, doctors will use a blood test to see when a patient's own immune system has recovered …

This study looks at how well a live shingles vaccine prevents shingles over 6 years in adults aged 40 and older. It follows about 24,740 people who were in an earlier vaccine trial, comparing those who got the vaccine first to those who got it later. Researchers will track new sh…

This study is testing whether the Shingrix vaccine, already used to prevent shingles, can also lower the risk of dementia in adults aged 76 and older. Over 33,000 participants in Finland will receive either the vaccine or a placebo. Researchers will track new dementia diagnoses o…

This large study in Denmark is testing whether the shingles vaccine (Shingrix) can do more than prevent shingles—it may also lower the risk of heart attacks, strokes, and dementia. About 162,000 adults aged 65 and older will either get the vaccine or no vaccine, and researchers w…

This study tests two different approaches to prevent cytomegalovirus (CMV) disease in adults who have received a kidney from a CMV-positive donor but are themselves CMV-negative. One group will take daily antiviral medicine for 200 days after transplant, while the other group wil…

This study tests whether the oral medication venlafaxine, typically used for depression, can prevent postherpetic neuralgia—a persistent nerve pain that often follows a shingles rash. Researchers will enroll 832 adults who have had a shingles rash for less than 30 days and are ex…

This study is testing whether the shingles vaccine (RZV) works and is safe for adults with autoimmune rheumatic diseases like rheumatoid arthritis or lupus who are taking immune-suppressing drugs. Two hundred participants will receive two doses of the vaccine. Researchers will me…

This phase 2 trial tests a vaccine called CMV-MVA Triplex, given to stem cell donors before they donate. The goal is to boost the donor's immunity against cytomegalovirus (CMV), which can then be passed to the transplant patient. Researchers hope this will prevent CMV infection i…

This study looks at whether giving letermovir for a longer time (up to 28 weeks) can prevent cytomegalovirus (CMV) infection in Chinese adults who have a high risk of reactivation after a stem cell transplant. Participants must be at least 18, have had a stem cell transplant, and…

This study compares a new drug called leymovir to the standard drug valganciclovir for preventing cytomegalovirus (CMV) infection in 290 Chinese kidney transplant recipients. Leymovir targets a different part of the virus, which may reduce side effects like bone marrow suppressio…

This study looks at whether electroacupuncture (a type of acupuncture with mild electric pulses) can help relieve pain from shingles and reduce the chance of long-term nerve pain. About 228 adults with shingles will be split into three groups: one gets electroacupuncture plus sta…

This study tests whether adding a newer pain medication called mirogabalin to standard treatment provides better pain relief for people with shingles. About 750 adults with moderate to severe shingles pain will receive either standard care alone or standard care plus mirogabalin.…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce pain and improve daily life for people with post-herpetic neuralgia (long-term nerve pain after shingles). About 34 adults aged 35-65 with persistent pain will receive the sti…

This study compares two treatments for long-lasting nerve pain after shingles (postherpetic neuralgia). Researchers will give 50 adults either a nerve block or a radiofrequency treatment and measure pain levels. The goal is to find which option works better for easing this stubbo…

This study tests whether a loxoprofen patch can safely reduce pain from shingles (herpes zoster). Researchers will compare standard treatment alone to standard treatment plus the patch in 750 adults with moderate to severe pain. The goal is to see if the patch provides better pai…

This study tests whether adding the muscle relaxant baclofen to standard shingles treatment can better reduce moderate to severe pain. Researchers will enroll 750 adults with shingles rash for less than 90 days. Participants will receive either baclofen plus usual care or usual c…

This study tests whether adding the antidepressant tulodesvenlafaxine to standard shingles treatment can better relieve pain. It includes 750 adults with moderate to severe shingles pain. The goal is to see if this drug reduces pain scores more than usual care alone.

This study tests whether a flurbiprofen patch can safely reduce pain in people with shingles (herpes zoster). About 750 adults with moderate to severe pain will either receive the patch plus standard treatments (antivirals, opioids) or standard treatments alone. The goal is to se…

This study tests whether the antidepressant desvenlafaxine can reduce pain from shingles (herpes zoster) better than standard treatments alone. Researchers will enroll 750 adults with moderate to severe pain and compare those taking desvenlafaxine plus usual care to those receivi…

This study tests whether a new oral medication called crisugabalin can provide better pain relief for people with shingles (herpes zoster) compared to standard treatments. The trial will enroll 750 adults with moderate to severe shingles pain. Participants will receive either cri…

This study aims to collect samples and medical information from people of all ages who have or have been exposed to viral infections, including COVID-19 and herpes. Researchers want to understand how viruses affect healthy individuals versus those with weakened immune systems. Pa…

This study looks at people who have had unusually severe or long-lasting viral infections, like serious cases of herpes, HPV, or the flu. Researchers want to find out if these people have hidden immune system or genetic problems that make them more vulnerable. Up to 600 participa…

This study collects blood, bone marrow, and tissue samples from people with HIV, KSHV, or certain cancers to help researchers learn more about these diseases. Participants must be 18 or older and may have HIV, KSHV, or related conditions. No treatment is given; the goal is to gat…

This study follows 600 people with GATA2 deficiency, a genetic disorder affecting the immune system and other body systems. Researchers aim to understand the full range of health problems it causes and why it affects people differently. Participants will have yearly check-ups for…

This study looks at how the immune system changes with age and how that affects the risk of infections in people 60 and older. Researchers will collect blood, urine, stool, and other samples from elderly patients with infections and healthy older adults. By analyzing immune cells…

This study aims to improve how doctors evaluate and manage people who have been exposed to bioterrorism agents (like anthrax) or emerging infectious diseases (like SARS or new flu strains). Up to 200 participants, including patients and healthcare workers, will be monitored and t…

This study is looking at 100 adult patients who have had an organ or stem cell transplant and later developed a CMV infection that is resistant or hard to treat with standard antiviral drugs. Researchers want to find out how common this problem is and what factors make it more li…

This study looks at how well the shingles vaccine (Shingrix) works in people with lupus compared to healthy people of the same age and sex. Researchers will measure immune cell responses after two doses and follow participants for up to 5 years. The goal is to understand if the v…

This study analyzes dried blood spots from 630 newborns to find protein and RNA markers that could predict which babies with congenital CMV will develop hearing loss or other problems. Researchers will compare samples from infected babies who had complications, those who did not,…

This study aims to find genetic mutations that cause chronic active Epstein-Barr virus (CAEBV), a rare and serious disease mainly affecting children and young adults. Researchers will analyze blood and tissue samples from up to 50 patients and 150 relatives, plus anonymous donor …

This observational study follows 350 adults with blood cancers like lymphoma or multiple myeloma who are being treated with bispecific antibodies. Researchers will track how often infections occur, how severe they are, and what factors raise infection risk. The goal is to better …

This study looks at why some teenagers and young adults feel tired for months after getting Epstein-Barr virus (the virus that causes mono). Researchers will follow 150 infected people and 150 healthy people for six months, using brain scans, immune tests, and questionnaires. The…

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study looks at how the Shingrix vaccine (for shingles) works in people with psoriasis or myelofibrosis who are taking drugs that weaken their immune system. Researchers will compare their immune response to that of similar patients not on these drugs. The goal is to understa…

This study is looking at whether early signs of inflammation in the blood can help identify which patients with infections are at risk for serious complications like sepsis. Researchers will follow 4,200 adults with confirmed or suspected infections, as well as healthy controls, …

This study reviews medical records of 230 children in Italy who received a stem cell transplant between 2018 and 2020. Researchers want to understand how common and costly cytomegalovirus (CMV) reactivation is in these young patients. The goal is to give doctors and health offici…

This study is looking for immune system markers that might predict whether a pregnant woman with a first-time HCMV infection will pass the virus to her unborn baby. Researchers will study blood samples from 90 pregnant women and their newborns to see which immune responses are li…

This study looks at how the antibiotic ceftazidime avibactam behaves in 30 children with severe infections who are in intensive care, some on life support. Researchers will measure drug levels in the blood to understand the right dose. The goal is to improve treatment for life-th…

This study follows 40 lung transplant patients who are at high risk for CMV infection because the donor had CMV but the recipient did not. Researchers want to learn how often the virus breaks through during standard antiviral treatment with valganciclovir. They will also track si…

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections, especially those with liver problems or on life support like ECMO. Researchers will measure drug levels in the blood to understand dosing needs. About 60 children in intensive …

This study will collect data from 2,000 children admitted to pediatric intensive care units (PICUs) with severe infections across major Chinese cities. Over 10 years, researchers will track which germs cause these infections, how they are treated, and patient outcomes. The goal i…

This study looks at two common antibiotic combinations given to hospitalized adults with infections: vancomycin plus piperacillin-tazobactam, or vancomycin plus cefepime. The goal is to see if one is less likely to cause kidney injury than the other, using more sensitive markers …

This study looks at how electroacupuncture might affect immune cells in people with shingles (herpes zoster). Researchers will compare standard medication alone versus medication plus electroacupuncture in 8 women aged 50-70. The goal is to see if electroacupuncture changes immun…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study collects information from 450 newborns who fail their initial hearing screening. Doctors will test them for congenital CMV, a common infection that can cause hearing loss and other problems. The goal is to see how often CMV is found and to improve follow-up care for af…

This study reviews medical records of 10 adult transplant patients who have a hard-to-treat CMV infection along with severe kidney disease or kidney failure. Researchers want to see how safe the drug maribavir is for these patients. No new treatments or procedures are given; the …

This observational study looks at whether people with shingles (herpes zoster) have a higher risk of vascular dementia—memory loss from reduced blood flow to the brain. Researchers will analyze tiny particles called exosomes in blood samples from 375 participants over 12 months. …

This pilot study is testing whether a smart wristband can accurately measure drug levels in sweat compared to standard blood tests. Researchers will collect sweat, saliva, and blood samples from 100 patients with chronic or infectious diseases who are taking medications like cycl…

This study is looking for new ways to diagnose sepsis, a life-threatening reaction to infection, earlier in the emergency room. Researchers will study the immune responses of 3,300 adults with suspected infections to find patterns that signal sepsis. The goal is to improve diagno…