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Immune cells from donors take on viruses in transplant patients

NCT ID NCT03665675

Recruiting now Disease control Sponsor: Sumithira Vasu Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tests whether immune cells from a donor can safely fight cytomegalovirus (CMV) or adenovirus (AdV) infections in people who have had a stem cell or solid organ transplant. About 20 participants will receive these virus-specific T-cells intravenously. The main goals are to check for side effects and see if the treatment can control the virus.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
donor virus-specific T-cells (CMV or adenovirus)
What this could lead to
If it works, this could offer a new way to control serious viral infections after organ or stem cell transplants, reducing the need for antiviral drugs.
What could go wrong
This is a very early, small pilot study (20 people). It may not work for everyone, and there are risks like graft-versus-host disease or infusion reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

adenoviridae infectious disease cytomegalovirus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADENOVIRUS ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION RECIPIENT CYTOMEGALOVIRUS DONOR SOLID ORGAN TRANSPLANTATION RECIPIENT

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Nationwide Children's Hospital

    RECRUITING

    Columbus, Ohio, 43205, United States

  • Ohio State University Comprehensive Cancer Center

    SUSPENDED

    Columbus, Ohio, 43210, United States

More trials for these conditions

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