Can specially grown immune cells from donors beat viruses that won't go away?
NCT ID NCT06926894
First seen Jul 30, 2026 · Last updated Jul 31, 2026 · Updated 1 time
Summary
This early-phase trial is testing whether immune cells called R-MVST cells, grown quickly from a healthy donor, can safely fight off stubborn viral infections (EBV, CMV, adenovirus, or BK virus) in children and young adults with weakened immune systems. Participants have not responded to standard treatments. The study will closely monitor for side effects, including graft-versus-host disease, and check whether the infusion lowers viral levels and helps the body recover its own antiviral defenses.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Rapidly generated virus specific T (R-MVST) cells from a healthy donor
- What this could lead to
- If it works, this approach could offer a new way to treat severe viral infections in patients with weak immune systems who have not responded to standard treatments.
- What could go wrong
- This is a very early phase 1 trial with only 18 participants, so safety and feasibility are the main focus. There is a risk of graft-versus-host disease or other serious side effects from the donor cells.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Columbia University Medical Center / New-York Presbyterian
RECRUITINGNew York, New York, 10032, United States
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Other studies related to the condition(s) this trial covers.
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