Lab-Grown immune cells take aim at Life-Threatening viruses in vulnerable patients
NCT ID NCT06027879
First seen Jun 29, 2026 · Last updated Jun 30, 2026 · Updated 1 time
Summary
This study tests whether specially grown immune cells can fight three common viruses—adenovirus, CMV, and EBV—in people whose immune systems are weak due to a stem cell or organ transplant, or an inherited immune disorder. The cells are made from a donor's blood and trained to recognize and attack the virus. The goal is to see if this treatment is safe and can clear the infection when standard therapies have failed.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- virus-specific T cells made using gamma capture technology
- What this could lead to
- If it works, this approach could offer a faster, more affordable way to treat dangerous viral infections in people with compromised immune systems, potentially saving lives.
- What could go wrong
- This is an early-phase trial with only 25 participants, so results may not apply to everyone. There is a risk of graft-versus-host disease or other immune reactions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
UPMC Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15224, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can immune cells predict herpesvirus danger in transplant patients?
- Can a new immune drug outsmart Hard-to-Treat tumors?
- Can specially grown immune cells from donors beat viruses that won't go away?
- Immune cell levels may predict who will develop severe CMV after transplant
- Hidden immune fire: could CMV or autoimmunity be fueling HIV-Related inflammation?
- Newborn blood spots may reveal hidden risks from common virus