New drug aims to stop kidney transplant rejection without antibodies

NCT ID NCT07219043

Recruiting now Disease control Sponsor: Biogen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 8 times

Summary

This study tests a drug called felzartamab in people who received a kidney transplant and later developed microvascular inflammation (MVI), a type of injury to small blood vessels in the new kidney that can lead to serious problems. The trial includes 81 participants who will receive either felzartamab or a placebo for 24 weeks, followed by an open-label phase where everyone gets the drug. Researchers will check for signs of inflammation through kidney biopsies and lab tests over about a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: felzartamab
What this could lead to: If successful, this could lead to a new treatment for isolated microvascular inflammation in kidney transplant recipients, potentially preserving kidney function and preventing graft loss.
What could go wrong: This is an early Phase 2 trial with only 81 participants, so results may not be conclusive. The drug may not reduce inflammation better than placebo, and there are risks from kidney biopsies and potential side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

endotheliitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MICROVASCULAR INFLAMMATION

Contacts and locations

Locations

Alberta Health Services (AHS) - University of Alberta Hospital
RECRUITING

Edmonton, Alberta, T6G 2R3, Canada
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Centre Hospitalier Universitaire (CHU) de Bordeaux - Hôpital Pellegrin
RECRUITING

Bordeaux, 33000, France
Centre Hospitalier Universitaire (CHU) de GreNble Alpes - Hôpital Michallon
RECRUITING

La Tronche, 38700, France
Centre Hospitalier Universitaire (CHU) de Toulouse - Hôpital de Rangueil
RECRUITING

Toulouse, 31400, France
Charité - Universitätsmedizin Berlin
RECRUITING

Berlin, 10117, Germany
Cleveland Clinic
RECRUITING

Cleveland, Ohio, 44195, United States
Clínica Privada Vélez Sarsfield
RECRUITING

Córdoba, 5000, Argentina
Cooperman Barnabas Medical Center
RECRUITING

West Orange, New Jersey, 07039, United States
Duke University Hospital
RECRUITING

Durham, North Carolina, 27710, United States
Hospices Civils de Lyon - Hôpital Édouard Herriot
RECRUITING

Lyon, 69003, France
Hospital Clínic de Barcelona
RECRUITING

Barcelona, 8036, Spain
Hospital Del Mar
RECRUITING

Barcelona, 8003, Spain
Hospital Universitario Miguel Servet
RECRUITING

Zaragoza, 50009, Spain
Hospital Universitario Vall d'Hebron
RECRUITING

Barcelona, 8035, Spain
Hospital de Base da Faculdade de Medicina de São José do Rio Preto
RECRUITING

Vila São José, São José Do Rio Preto, 15090-000, Brazil
Hospital do Rim - Fundação Oswaldo Ramos
RECRUITING

São Paulo, 04038-002, Brazil
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
Institut klinicke a experimentalni mediciny (IKEM)
RECRUITING

Prague, 104 21, Czechia
Instituto de Trasplante y Alta Complejidad (ITAC)
RECRUITING

Buenos Aires, Ciudad Autónoma de Buenos Aires (caba), 1425, Argentina
Keck Hispital of University of Southern California (USC)
RECRUITING

Los Angeles, California, 90033, United States
Loma Linda University Medical Center
RECRUITING

Loma Linda, California, 92350, United States
Mayo Clinic Rochester
RECRUITING

Rochester, Minnesota, 55905, United States
Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Medizinische Universität Wien
RECRUITING

Vienna, 1090, Austria
Princess Alexandra Hospital
RECRUITING

Brisbane, Queensland, 4102, Australia
Providence St. Joseph Hospital Orange
RECRUITING

Orange, California, 92868, United States
Sutter Health - California Pacific Medical Center
RECRUITING

San Francisco, California, 94115, United States
The Ohio State University
RECRUITING

Columbus, Ohio, 43210, United States
The University of Kansas Medical Center
RECRUITING

Kansas City, Kansas, 66160, United States
Universitaetsklinikum Carl Gustav Carus Dresden
RECRUITING

Dresden, 1307, Germany
University of California San Fransisco (UCSF) Medical Center
RECRUITING

San Francisco, California, 94158, United States
University of Michigan Medical Center
RECRUITING

Ann Arbor, Michigan, 48109-5650, United States
University of Nebraska Medical Center
RECRUITING

Omaha, Nebraska, 68198, United States
University of Texas Southwestern Medical Center
RECRUITING

Dallas, Texas, 75390, United States
University of Washington Medical Center
RECRUITING

Seattle, Washington, 98195, United States
Universitätsklinikum Hamburg-Eppendorf
RECRUITING

Hamburg, 20251, Germany
Universitätsspital Zürich
RECRUITING

Zurich, 8091, Switzerland
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Virginia Commonwealth University (VCU) Medical Center (Main Hospital) Hume-Lee Transplant Center
RECRUITING

Richmond, Virginia, 23298, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.

New hope for kidney transplant patients: extended drug trial targets rejection