Biogen

This study aims to find the right dose and check the safety of the drug omaveloxolone (SKYCLARYS®) in children and teenagers aged 2 to 15 with Friedreich's ataxia. The drug is already approved for people 16 and older, but researchers need to understand how younger bodies process …

This study is testing an investigational drug called felzartamab for people with primary membranous nephropathy (PMN), an autoimmune disease that damages the kidneys' filters. The main goal is to see if felzartamab works better than the standard drug tacrolimus at reducing harmfu…

This study is testing a drug called omaveloxolone (SKYCLARYS®) in children and teenagers aged 2 to 15 with Friedreich's ataxia (FA), a rare genetic disease that affects movement and coordination. The drug is already approved for adults, but its safety and effects in younger patie…

This study monitors the long-term safety of tofersen (Qalsody®) in Chinese adults with a specific genetic form of ALS. Researchers will track side effects and how the drug moves through the body in 12 participants over one year. The drug is already approved in China, so this stud…

This study is testing an experimental drug called felzartamab in people who have received a kidney transplant and whose immune system is attacking the new kidney. About 120 participants will be randomly assigned to receive either felzartamab or a placebo (an inactive substance) t…

This study is testing whether an experimental drug called felzartamab can reduce inflammation in transplanted kidneys. Researchers will enroll 81 kidney transplant patients who have developed microvascular inflammation, a condition where the body's immune system damages the kidne…

This study is testing an investigational drug called litifilimab for people with active skin lupus (cutaneous lupus) who haven't gotten better with standard antimalarial therapy. About 450 participants will receive either the drug or a placebo via injection every four weeks for 2…

This study is testing a drug called salanersen (BIIB115) in babies who have a genetic diagnosis of spinal muscular atrophy (SMA) but have not yet shown any symptoms. The goal is to see if starting treatment very early can prevent the onset of SMA symptoms or make them much less s…

This study is testing an investigational drug called felzartamab to see if it can protect the kidneys of adults with IgA nephropathy, a disease that causes protein to leak into the urine and can lead to kidney failure. Researchers will compare felzartamab to a placebo (inactive s…

This is the first study to test a new experimental drug called BIIB142 in people. Researchers want to see if it's safe and how the body handles it. The study involves 78 healthy adults who will receive either the drug or a placebo. The main goal is to find the highest dose that d…

This study aims to learn about the safety of the SMA drug Spinraza (nusinersen) during pregnancy. Researchers will follow about 20 pregnant women with SMA who received the drug before or during pregnancy, tracking their health and their babies' health for up to two years after bi…

This study aims to understand how symptoms of postpartum depression change after people start taking zuranolone, a prescription medication for this condition. Researchers will follow 200 participants in the U.S. who have a new prescription, asking them to complete short online su…

This study aims to see if a new liquid tablet form of the drug omaveloxolone (SKYCLARYS®) is processed by the body the same way as the currently available capsules. It involves about 70 healthy adults who will take both forms of the drug in a specific order, with a break in betwe…

This is a very early study to check the safety of a new drug called BIIB145, which is being developed for multiple sclerosis (MS). Researchers will give the drug to 104 healthy volunteers to see what side effects occur and how the body absorbs and processes it. The study will tes…

This study aims to understand the safety of the MS medication diroximel fumarate during pregnancy. Researchers will compare pregnancy outcomes and baby health across three groups: women who took this drug, those who took other MS medications, and those who took no MS medications …

This study aims to understand how the body processes the SMA drug nusinersen when it's delivered through a new implanted port system called ThecaFlex DRx, compared to the standard spinal injection method. The research involves about 58 people with Spinal Muscular Atrophy who are …