Biogen

This long-term study is testing higher doses of nusinersen (Spinraza) in people with spinal muscular atrophy who already completed a previous nusinersen study. The main goal is to check safety over several years, including side effects, heart health, and growth. Participants rece…

This study tested a drug called BIIB122 in 650 people with early-stage Parkinson's disease. The goal was to see if the drug could slow down the worsening of symptoms like movement problems and daily living tasks. Participants took either BIIB122 or a placebo daily for up to 3 yea…

This completed Phase 3 trial tested the oral drug dimethyl fumarate (Tecfidera) against an injected interferon in 156 children aged 10 to 17 with relapsing-remitting multiple sclerosis. The main goal was to see if the drug could prevent new brain lesions and control the disease s…

This study tested an experimental drug called BIIB091, alone or combined with an approved MS drug (diroximel fumarate), in 127 people with relapsing multiple sclerosis. The goal was to check safety and see if it reduces brain inflammation on MRI scans. Participants took pills twi…

This study tested a drug called RTA 408 (omaveloxolone) in 172 people with Friedreich's ataxia, a rare genetic disease that affects movement and coordination. The goal was to see if the drug is safe and can improve exercise ability and daily function. Participants took the drug o…

This phase 3 study tested the safety and tolerability of diroximel fumarate (Vumerity) in 136 East Asian adults with relapsing forms of multiple sclerosis. Participants took the drug for up to 48 weeks, and researchers monitored side effects, lab results, and drug levels in the b…

This study tested a drug called nusinersen (Spinraza) in 25 infants who have a genetic diagnosis of spinal muscular atrophy (SMA) but no symptoms yet. The drug is given through a spinal injection to help delay or prevent the need for breathing support or early death. The goal was…

This study tested the drug nusinersen (Spinraza) in 46 children under 3 years old with spinal muscular atrophy (SMA) who had previously received gene therapy but still had health challenges. The goal was to see if adding nusinersen could improve their muscle and movement abilitie…

This study tested a small, radioactive dose of BIIB080, an experimental Alzheimer's drug, in 5 healthy adults to see how it spreads in the brain and spinal cord. Researchers used PET scans to track the drug after a single injection into the spinal fluid. The main goal was to unde…

This completed Phase 1 study tested whether giving the drug litifilimab under the skin using an autoinjector or a wearable on-body injector works as well as using a traditional syringe. 404 healthy volunteers received the drug by one of the three devices. Researchers measured dru…

This study tested whether a tablet that dissolves in liquid works the same as the capsule form of the drug omaveloxolone (SKYCLARYS). The drug is already approved for Friedreich's ataxia, but some people have trouble swallowing capsules. Seventy healthy adults took both forms in …

This completed Phase 1 study in 22 healthy volunteers looked at whether omaveloxolone (a drug for Friedreich's ataxia) changes how the body processes omeprazole (a common stomach acid reducer). Participants took omeprazole alone and then together with omaveloxolone over 17 days. …

This study tested a new drug called BIIB800 against an approved drug, Actemra, in 300 healthy men. The goal was to see if the two drugs behave similarly in the body and are equally safe. Participants received a single injection and were monitored for side effects and drug levels.

This study looked at how the body processes the drug omaveloxolone (SKYCLARYS®) when taken as a whole capsule versus when the capsule contents are sprinkled over low-fat yogurt. 52 healthy adults took the drug both ways to see if the body absorbs it differently. The goal is to of…