New MS drug shows promise for asian patients in safety trial

NCT ID NCT05083923

Completed Disease control Sponsor: Biogen Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 study tested the safety and tolerability of diroximel fumarate (Vumerity) in 136 East Asian adults with relapsing forms of multiple sclerosis. Participants took the drug for up to 48 weeks, and researchers monitored side effects, lab results, and drug levels in the blood. The goal was to see if the drug is safe and tolerable for this specific population.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

diroximel fumarate (Vumerity)

What this could lead to

If successful, this could confirm that diroximel fumarate is a safe and tolerable treatment option for relapsing multiple sclerosis in East Asian patients.

What could go wrong

This is a single-arm, open-label study without a placebo or comparator, so results may not prove effectiveness. Side effects like flushing, stomach issues, or liver problems are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

multiple sclerosis relapsing-remitting multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RELAPSING FORMS OF MULTIPLE SCLEROSIS

Contacts and locations

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Locations

Beijing Hospital

Beijing, Beijing Municipality, 100006, China
Beijing Tiantan Hospital, Capital Medical University

Beijing, Beijing Municipality, 100050, China
Chiba University Hospital

Chiba, Chiba, 260-8677, Japan
Department of Neurosurgery, Tokyo Women's Medical University

Shinjuku-ku, Tokyo-To, 162-8666, Japan
Dongguan People's Hospital

Dongguan, Guangdong, 523059, China
Ebara Hospital

Ōta-ku, Tokyo-To, 145-0065, Japan
Ehime University Hospital

Toon-shi, Ehime, 791-0295, Japan
First Affiliated Hospital of Kunming Medical University

Kunming, Yun'nan, 650032, China
Fujian Medical University Union Hospital

Fuzhou, Fujian, 350001, China
Fukuoka University Hospital

Fukuoka, Fukuoka, 814-0180, Japan
General Hospital of Ningxia Medical University

Yinchuan, Ningxia Hui, 750004, China
Guangzhou First People's Hospital

Guangzhou, Guangdong, 510180, China
Hospital of the University of Occupational and Environmental Health

Kitakyushu-shi, Fukuoka, 807-8556, Japan
Iwate Medical University Uchimaru Medical Center

Morioka, Iwate, 020-8505, Japan
Jiangxi Provincial People's Hospital

Nanchang, Jiangxi, 330006, China
Juntendo University Hospital

Bunkyō City, Tokyo-To, 113-8431, Japan
Kansai Medical University Medical Center

Moriguchi-shi, Osaka, 570-8507, Japan
Lanzhou University Second Hospital

Lanzhou, Gansu, 730030, China
NHO Asahikawa Medical Center

Asahikawa-shi, Hokkaido, 070-8644, Japan
NHO Hokkaido Medical Center

Sapporo, Hokkaido, 063-0005, Japan
Nanfang Hospital of Southern Medical University

Guangzhou, Guangdong, 510515, China
National Center of Neurology and Psychiatry

Kodaira-shi, Tokyo-To, 187-8551, Japan
Niigata University Medical & Dental Hospital

Niigata, Niigata, 951-8520, Japan
Obihiro Kosei Hospital

Obihiro, Hokkaido, 080-0024, Japan
Renji Hospital Shanghai Jiaotong University School of Medicine - West Branch

Shanghai, Shanghai Municipality, 200001, China
Saitama Medical Center

Kawagoe-shi, Saitama, 350-8550, Japan
Shanxi Provincial People's Hospital

Taiyuan, Shanxi, 30012, China
Shengjing Hospital of China Medical University

Shengyang, Liaoning, 110004, China
Sichuan Provincial People's Hospital

Chengdu, Sichuan, 610072, China
Southern Tohoku Medical Clinic

Koriyama-shi, Fukushima, 963-8563, Japan
Tangdu Hospital, Fourth Military Medical University

Xi'an, Shan'xi, 710038, China
Tangshan Gongren Hospital

Tangshan, Hebei, 063003, China
The Affiliated Hospital of Inner Mongolia Medical University

Hohhot, Inner Mongolia, 10050, China
The First Affiliated Hospital of Anhui Medical University

Hefei, Anhui, 230022, China
The First Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, 150040, China
The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, 330006, China
The First Affiliated Hospital of Soochow University

Suzhou, Jiangsu, 215004, China
The First Affiliated Hospital of Sun Yat-sen University

Guangzhou, Guangdong, 510080, China
The First Hospital of Jilin University

Changchun, Jilin, 130021, China
The Second Affiliated Hospital of Guangzhou Medical University

Guangzhou, Guangdong, 510260, China
The Second Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, 150086, China
The Third Affiliated Hospital, Sun Yat-sen University

Guangzhou, Guangdong, 510630, China
Tianjin Medical University Affiliated General Hospital

Tianjin, Tianjin Municipality, 300052, China
Tohoku Medical and Pharmaceutical University Hospital

Sendai, Miyagi, 983-8512, Japan
Tohoku University Hospital

Sendai, Miyagi, 980-8574, Japan
Tokyo Womens Medical University Yachiyo Medical Center

Yachiyo, Chiba, 276-8524, Japan
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology

Wuhan, Hubei, 430030, China
University of Tsukuba Hospital

Tsukuba, Ibaraki, 305-8576, Japan
Wakayama Medical University Hospital

Wakayama, Wakayama, 641-8510, Japan
Xiangya Hospital, Central South University

Changsha, Hu'nan, 410008, China
Yamaguchi University Hospital

Ube-shi, Yamaguchi, 755-8505, Japan
Yokohama City University Hospital

Yokohama, Kanagawa, 236-0004, Japan