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New antibody drug aims to protect kidneys in PMN patients

NCT ID NCT06962800

Recruiting now Disease control Sponsor: Biogen Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 study tests a new drug called felzartamab in 180 people with primary membranous nephropathy (PMN), a kidney disease where the body's immune system attacks the kidneys. Felzartamab is a lab-made antibody designed to stop that attack. The study compares felzartamab to the standard drug tacrolimus. The main goal is to see if more patients achieve complete remission (low urine protein and stable kidney function) after 104 weeks of treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

felzartamab (a lab-made antibody given by IV)

What this could lead to

If successful, felzartamab could offer a new treatment option for people with PMN, potentially reducing kidney damage and delaying or avoiding kidney failure.

What could go wrong

This is a Phase 3 trial, but it's still experimental. Felzartamab may not work better than existing drugs, and side effects are possible. The study is not designed to cure PMN, only to control it.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

idiopathic membranous glomerulonephritis membranous glomerulonephritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY MEMBRANOUS NEPHROPATHY

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Academic Medical Research Institute

    RECRUITING

    Los Angeles, California, 90022, United States

    Contact Phone: •••-•••-••••

    Contact

  • Ajou University Hospital

    RECRUITING

    Suwon, Gyeonggido, 16499, South Korea

  • Apogee Clinical Research, LLC

    RECRUITING

    Huntsville, Alabama, 35805-4104, United States

    Contact Phone: •••-•••-••••

    Contact

  • Beijing Tsinghua Changgung Hospital

    RECRUITING

    Beijing, Beijing Municipality, 102218, China

  • CINME S.A. - Centro de Investigaciones Metabólicas

    RECRUITING

    Buenos Aires, C1056ABI, Argentina

    Contact Phone: •••-•••-••••

    Contact

  • Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada

    RECRUITING

    Buenos Aires, C1425, Argentina

    Contact Phone: •••-•••-••••

    Contact

  • Centro de Pesquisa Clínica de Nefrologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

    RECRUITING

    São Paulo, 05304-000, Brazil

    Contact Phone: •••-•••-••••

    Contact

  • Chang Gung Memorial Hospital

    RECRUITING

    Taoyuan, 33305, Taiwan

  • China Medical University Hospital

    RECRUITING

    Taichung, 40447, Taiwan

  • Chung-Ang University Hospital

    RECRUITING

    Seoul, 6973, South Korea

  • Clínica Privada Vélez Sarsfield

    RECRUITING

    Córdoba, X5016KET, Argentina

    Contact Phone: •••-•••-••••

    Contact

  • Concord Hospital

    RECRUITING

    Concord, New South Wales, 2138, Australia

  • Daqing Oilfield General Hospital

    RECRUITING

    Daqing, Heilongjiang, 163001, China

  • ECU Physicians Nephrology and Hypertension

    RECRUITING

    Greenville, North Carolina, 27834, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Elixia Health - Michigan Kidney Consultants, LLC - Elixia - PPDS

    COMPLETED

    Pontiac, Michigan, 48341, United States

  • Fu Yang People's Hospital - South Campus

    RECRUITING

    Fuyang, Anhui, 236006, China

  • Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto Hospital de Base - PPDS

    RECRUITING

    São José do Rio Preto, São Paulo, 15090-000, Brazil

    Contact Phone: •••-•••-••••

    Contact

  • Galaxy Hospital - Varanasi

    RECRUITING

    Varanasi, Uttar Pradesh, 221010, India

  • Gansu Provincial Hospital

    RECRUITING

    Lanzhou, Gansu, 730000, China

  • Gold Coast University Hospital

    RECRUITING

    Southport, Queensland, 4215, Australia

  • Griffith University Clinical Trial Unit

    RECRUITING

    Southport, Queensland, 4215, Australia

  • Hanyang University Seoul Hospital

    RECRUITING

    Seoul, 4763, South Korea

  • Henry Ford Hospital- A-Basement Research Pharmacy

    RECRUITING

    Detroit, Michigan, 48202-2608, United States

    Contact Phone: •••-•••-••••

    Contact

  • Hokkaido University Hospital

    RECRUITING

    Sapporo, Hokkaidô, 060-8648, Japan

  • Hospital Canselor Tuanku Muhriz UKM

    RECRUITING

    Cheras, WilayahPersekutuan KualaLumpur, 56000, Malaysia

  • Hospital Italiano de Buenos Aires

    RECRUITING

    Buenos Aires, C1199ABB, Argentina

    Contact Phone: •••-•••-••••

    Contact

  • Hospital Raja Permaisuri Bainun

    RECRUITING

    Perak, Pahang, 30450, Malaysia

  • Hospital Sao Lucas Da Pontificia Universidade Catolica Do Rio Grande Do Sul (PUCRS)

    RECRUITING

    Porto Alegre, Rio Grande do Sul, 90610-001, Brazil

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo

    RECRUITING

    Ribeirão Preto, São Paulo, 14051-140, Brazil

    Contact Phone: •••-•••-••••

    Contact

  • Hospital de Clinicas de Porto Alegre

    RECRUITING

    Porto Alegre, Rio Grande do Sul, 90560-030, Brazil

    Contact Phone: •••-•••-••••

    Contact

  • Hualien Tzu Chi Hospital

    RECRUITING

    Hualien City, Hualien, 970, Taiwan

  • Inje University Haeundae Paik Hospital

    RECRUITING

    Busan, 48108, South Korea

  • James J Peters Veterans Administration Medical Center - NAVREF - PPDS

    RECRUITING

    The Bronx, New York, 10468, United States

    Contact Phone: •••-•••-••••

    Contact

  • Japanese Red Cross Musashino Hospital

    RECRUITING

    Musashino-shi, Tokyo, 180-8610, Japan

  • Juntendo University Urayasu Hospital

    RECRUITING

    Urayasu-Shi, Chiba, 279-0021, Japan

  • Kagawa University Hospital

    RECRUITING

    Kita-Gun Uchiko-Cho, Kagawa-ken, 761-0793, Japan

  • Kaohsiung Chang Gung Memorial Hospital

    RECRUITING

    Kaohsiung City, 83301, Taiwan

  • Kaohsiung Medical University Chung-Ho Memorial Hospital

    RECRUITING

    Kaohsiung City, 80756, Taiwan

  • Knoxville Kidney Center, PLLC

    RECRUITING

    Knoxville, Tennessee, 37923-3624, United States

    Contact Phone: •••-•••-••••

    Contact

  • Lanzhou University Second Hospital

    RECRUITING

    Lanzhou, Gansu, 730030, China

  • Liverpool Hospital

    RECRUITING

    Liverpool, New South Wales, 2170, Australia

  • London Health Sciences Centre - Victoria Hospital

    RECRUITING

    London, Ontario, N6A 5W9, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • M.S. Ramaiah Medical College and Hospital

    RECRUITING

    Bangalore, Karnataka, 560054, India

  • MacKay Memorial Hospital

    RECRUITING

    Taipei, 104, Taiwan

  • Manipal Hospital Bangalore

    RECRUITING

    Bangalore, Karnataka, 560017, India

  • Max Super Speciality Hospital - Saket

    RECRUITING

    New Delhi, National Capital Territory of Delhi, 110017, India

  • Monash Health

    RECRUITING

    Clayton, Victoria, 3168, Australia

  • National Cheng Kung University Hospital

    RECRUITING

    Tainan, 70403, Taiwan

  • National Hospital Organization Chiba Medical Center Chibahigashi National Hospital

    RECRUITING

    Chia-shi, Chiba, 260-8712, Japan

  • Nephrotex Research Group

    RECRUITING

    Dallas, Texas, 75231-0929, United States

    Contact Phone: •••-•••-••••

    Contact

  • Niigata University Medical ＆ Dental Hospital

    RECRUITING

    Niigata, Niigata, 951-8520, Japan

  • Nil Ratan Sircar Medical College and Hospital

    RECRUITING

    Kolkata, West Bengal, 700014, India

  • Nizams Institute of Medical Sciences

    RECRUITING

    Hyderabad, Andhra Pradesh, 500082, India

  • Noble Hospital

    RECRUITING

    Pune, Maharashtra, 411013, India

  • Organización Médica de Investigación

    RECRUITING

    Buenos Aires, C1015ABO, Argentina

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • Osmania General Hospital

    RECRUITING

    Hyderabad, Andhra Pradesh, 500012, India

  • Peking University First Hospital - Changqiao Campus

    RECRUITING

    Xichengqu Beijing, Beijing Municipality, 100034, China

  • Peking University Shenzhen Hospital

    RECRUITING

    Shenzhen, Guangdong, 518036, China

  • Postgraduate Institute of Medical Education & Research (PGIMER)

    RECRUITING

    Chandigarh, 160012, India

  • Prince Court Medical Centre

    RECRUITING

    Kuala Lumpur, 50450, Malaysia

  • Qilu Hospital of Shandong University

    RECRUITING

    Jinan, Shandong, 250012, China

  • Regency Health Super Specialty Hospital - Lucknow

    RECRUITING

    Lucknow, Uttar Pradesh, 226022, India

  • Royal Brisbane and Women s Hospital

    RECRUITING

    Herston, Queensland, 4006, Australia

  • Saitama Medical University Hospital

    RECRUITING

    Iruma-Gun Moroyama-Machi, Saitama, 350-0451, Japan

  • Santa Casa de Misericórdia de Belo Horizonte

    RECRUITING

    Belo Horizonte, Minas Gerais, 30150-221, Brazil

    Contact Phone: •••-•••-••••

    Contact

  • Seoul National University Hospital

    RECRUITING

    Seoul, Seoul Teugbyeolsi, 3080, South Korea

  • Sir Ganga Ram Hospital

    RECRUITING

    New Delhi, National Capital Territory of Delhi, 110060, India

  • Sir Run Run Shaw Hospital Zhejiang University School of Medicine - Qingchun Campus

    RECRUITING

    Hangzhou, Zhejiang, 310016, China

  • Social Medical Corporation Yuuaikai Yuuai Medical Center

    RECRUITING

    Tomigusuku-Shi, Okinawa, 901-0224, Japan

  • St George Hospital

    RECRUITING

    Kogarah, New South Wales, 2217, Australia

  • Stanford University

    RECRUITING

    Stanford, California, 94305-2200, United States

    Contact Phone: •••-•••-••••

    Contact

  • Sunshine Hospital - Australia

    RECRUITING

    St Albans, Victoria, 3021, Australia

  • Taichung Veterans General Hospital

    RECRUITING

    Taichung, 40705, Taiwan

  • Taipei Medical University Hospital - PPDS

    RECRUITING

    Taipei, 11031, Taiwan

  • Taipei Municipal Wanfang Hospital

    RECRUITING

    Taipei, 116, Taiwan

  • The Affiliated Hospital of Guizhou Medical University

    RECRUITING

    Guiyang, Guizhou, 550004, China

  • The Affiliated Hospital of Qingdao University - Xihaian Campus

    RECRUITING

    Qingdao, Shandong, 266555, China

  • The First Affiliated Hospital of Guangxi Medical University

    RECRUITING

    Nanning, Guangxi, 530021, China

  • The First Affiliated Hospital of Henan Science and Technology University - Jinghua Campus

    RECRUITING

    Luoyang, Henan, 471003, China

  • The First Affiliated Hospital of Xian Jiaotong University

    RECRUITING

    Xi'an, Shaanxi, 710061, China

  • The First Hospital of Hebei Medical University

    RECRUITING

    Shijiazhuang, Hebei, 50031, China

  • The Kitasato Institute Kitasato University Hospital

    RECRUITING

    Sagamihara-Shi Minami-Ku, Kanagawa, 252-0375, Japan

  • The Nephrology Group, Inc. - Fresno

    RECRUITING

    Fresno, California, 93720-2989, United States

    Contact Phone: •••-•••-••••

    Contact

  • The People's Hospital of Guangxi Zhuang Autonomous Region

    RECRUITING

    Nanning, Guangxi, 530021, China

  • The Second Affiliated Hospital of Xian Jiaotong University

    RECRUITING

    Xi'an, Shaanxi, 710004, China

  • The Second Affiliated Hospital, Zhejiang University School of Medicine

    RECRUITING

    Hangzhou, Zhejiang, 310009, China

  • The Second Hospital of Hebei Medical University - Main

    RECRUITING

    Shijiazhuang, Hebei, 50000, China

  • The Second Hospital of Shandong University

    RECRUITING

    Jinan, Shandong, 250033, China

  • The Second Xiangya Hospital of Central South University

    RECRUITING

    Changsha, Hunan, 410011, China

  • Townsville Hospital

    RECRUITING

    Douglas, Queensland, 4814, Australia

  • UCLA Health Connie Frank Kidney Transplant Center and General Nephrology

    RECRUITING

    Los Angeles, California, 90095-8344, United States

    Contact Phone: •••-•••-••••

    Contact

  • UCSF Medical Center

    RECRUITING

    San Francisco, California, 94143-2205, United States

    Contact Phone: •••-•••-••••

    Contact

  • University Hospitals Cleveland Medical Center

    RECRUITING

    Cleveland, Ohio, 44106-1716, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University of Miyazaki Hospital

    RECRUITING

    Miyazaki, Miyazaki, 889-1692, Japan

  • University of Texas Medical Branch

    RECRUITING

    League City, Texas, 77573, United States

    Contact Phone: •••-•••-••••

    Contact

  • University of Wisconsin School of Medicine and Public Health

    RECRUITING

    Madison, Wisconsin, 53792-0001, United States

    Contact Phone: •••-•••-••••

    Contact

  • Vanderbilt University Medical Center

    RECRUITING

    Nashville, Tennessee, 37204-3609, United States

    Contact Phone: •••-•••-••••

    Contact

  • Westmead Hospital

    RECRUITING

    Westmead, New South Wales, 2145, Australia

  • Yantai Yuhuangding Hospital

    RECRUITING

    Yantai, Shandong, 264000, China

  • Yokohama City University Hospital

    RECRUITING

    Yokohama, Kanagawa, 236-0004, Japan

  • Yueyang People Hospital

    RECRUITING

    Yueyang, Hunan, 414000, China

  • Zhongshan Hospital Xiamen University

    RECRUITING

    Xiamen, Fujian, 361004, China

  • Zhujiang Hospital of Southern Medical University

    RECRUITING

    Guangzhou, Guangdong, 510280, China