New gel could outperform standard therapy for kidney disease

NCT ID NCT05696613

Recruiting now Disease control Sponsor: Cerium Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial is testing a new gel called SNP-ACTH (1-39) against the standard drug rituximab in 148 adults with primary membranous nephropathy, a rare kidney condition. The goal is to see if the gel can better reduce protein in the urine and protect kidney function over 24 months. Participants are at high risk of kidney decline and will be randomly assigned to one of the two treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SNP-ACTH (1-39) Gel
What this could lead to: If this works, it could offer a new treatment option for people with a rare kidney disease, potentially reducing protein leakage and preserving kidney function better than current therapies.
What could go wrong: This is still an early-stage Phase 3 trial with only 148 participants, so results may not apply to everyone. The gel may not prove superior to rituximab, and side effects are still being studied.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

idiopathic membranous glomerulonephritis kidney disorder membranous glomerulonephritis nephritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRIMARY MEMBRANOUS NEPHROPATHY

Contacts and locations

Locations

AIIMS
RECRUITING

Raipur, Chhattisgarh, 492099, India
Academic Medical Research Institute
RECRUITING

Los Angeles, California, 90022, United States
Apex Hospitals
RECRUITING

Jaipur, Rajasthan, 302017, India
Center for Advanced Kidney Research, PLC
RECRUITING

Saint Clair Shores, Michigan, 48080, United States
Costal Medical Research
RECRUITING

Brunswick, Georgia, 31520, United States
Fides Clinical Research
RECRUITING

Atlanta, Georgia, 30342, United States
Galaxy Hospital
RECRUITING

Varanasi, Uttar Pradesh, 221010, India
Genesis Clinical Research
RECRUITING

Tampa, Florida, 33603, United States
Insight Hospital and Medical Center Chicago
RECRUITING

Chicago, Illinois, 60615, United States
KLE Hospital
RECRUITING

Belagavi, Karnataka, 590010, India
Muljibhai Patel Urological Hospital
RECRUITING

Nadiād, Gujarat, India
NYU Langone Health
RECRUITING

New York, New York, 10016, United States
Nephrology Associates of Northern Virginia
RECRUITING

Fairfax, Virginia, 22033, United States
North America Research Institute
RECRUITING

San Dimas, California, 91773, United States
P&I Clinical Research LLC
RECRUITING

Lufkin, Texas, 75904, United States
PGIMER
RECRUITING

Chandigarh, Punjab, 160012, India
Prolato Clinical Research Center
RECRUITING

Houston, Texas, 77054, United States
RecioMed Clinical Research Network, Inc.
RECRUITING

Boynton Beach, Florida, 33472, United States
Regional Kidney Wellness Centre
RECRUITING

Brampton, Ontario, L6T 0H9, Canada
Reliant Medical Research, LLC
RECRUITING

Miami, Florida, 33165, United States
SMS Medical College and Hospital
RECRUITING

Jaipur, Rajasthan, 302004, India
Saraswati Kidney Care Center
RECRUITING

Nagpur, Maharashtra, 440015, India
Sir Ganga Ram Hospital
RECRUITING

New Delhi, National Capital Territory of Delhi, 10060, India
South Florida Nephrology Research
RECRUITING

Coral Springs, Florida, 33071, United States
Therafirst Medical Center
RECRUITING

Fort Lauderdale, Florida, 33308, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Virginia
RECRUITING

Charlottesville, Virginia, 22908, United States
Valiance Clinical Research
RECRUITING

Tarzana, California, 91356, United States
Vedanta Hospitals
RECRUITING

Guntur, Andhra Pradesh, 522001, India
Vijaya Super Speciality Hospital
RECRUITING

Nellore, Andhra Pradesh, 524001, India
Vista Health Research, LLC
RECRUITING

Miami, Florida, 33176, United States

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