Herpesviridae infectious disease

This early-stage trial tested whether a new herpes vaccine called HSV529 is safe for people. Researchers gave the vaccine or a placebo to 69 healthy adults aged 18 to 40, some of whom had herpes and some who did not. Participants received three shots over six months and were moni…

This study tested an experimental mRNA vaccine (mRNA-1647) for cytomegalovirus (CMV) in healthy teens (9–15 years) and young women (16–25 years). The goal was to see if the vaccine is safe and triggers a strong immune response. Participants received either the vaccine or a placeb…

This study tested a vaccine called Triplex® in 94 adults who have both HIV and cytomegalovirus (CMV). The goal was to see if the vaccine is safe and helps the immune system control CMV. Participants received two shots of the vaccine or a placebo over 4 weeks and were followed for…

This study looked at how safe and effective two shingles vaccines (Zostavax and Shingrix) are in people with rheumatoid arthritis who are taking the drug abatacept. About 154 adults took part, and researchers measured their immune response and any side effects. The goal was to se…

This study tested an experimental mRNA vaccine called mRNA-1647 to see if it is safe and triggers an immune response against cytomegalovirus (CMV). The trial involved 315 healthy adults aged 18 to 40, some of whom had never been exposed to CMV. Researchers measured side effects a…

This study tested a new vaccine designed to prevent Epstein-Barr virus (EBV) infection, which causes most cases of infectious mononucleosis (mono). Twenty-five healthy adults aged 18 to 25 who had never been infected with EBV received either the vaccine or a placebo. The goal was…

This early-stage study tested a new mRNA vaccine called IN001 for preventing shingles in 150 healthy adults aged 50 to 69. The main goals were to check the vaccine's safety, side effects, and how well it triggers the immune system. Researchers gave different doses to find the bes…

This study tested the safety and immune response of several Moderna mRNA vaccines for COVID-19, seasonal flu, RSV, and CMV in 308 healthy adults aged 18 to 75. Researchers monitored side effects and measured antibody levels after vaccination. The goal was to ensure the vaccines a…

This early-stage trial tests a new vaccine against cytomegalovirus (CMV), a common virus that can cause serious problems in newborns and people with weakened immune systems. The study involves 339 healthy adults aged 18 to 50, who will receive different doses of the vaccine or a …

This study is a long-term follow-up of a phase 2 trial testing Moderna's mRNA-1647 vaccine against cytomegalovirus (CMV). It involves 135 adults who previously received the vaccine or a placebo. Researchers are checking how long the immune response lasts and whether a booster dos…

This study followed over 7,500 older adults who received the shingles vaccine to see how well it prevents shingles over many years. Researchers also tested giving extra doses to some participants. The goal was to understand how long protection lasts and whether booster shots are …

This study tested a two-dose shingles vaccine (HZ/su) in 1,430 adults aged 50 and older who had already experienced shingles. The goal was to see if the vaccine could prevent the virus from coming back and to check its safety and immune response. Participants received either the …

This study tested whether giving the RSV vaccine (Abrysvo) and the shingles vaccine (Shingrix) at the same doctor's visit is safe and works as well as giving them separately. About 526 adults aged 50 and older took part. Researchers measured immune responses and tracked side effe…

This early-stage trial tests a new vaccine called SPYVLP01 designed to protect against cytomegalovirus (CMV), a common virus that can cause serious problems in newborns and people with weak immune systems. The study involves 120 healthy adults aged 18 to 50 and will check if the …

This study tested a new oral drug called pritelivir against standard treatments (foscarnet, cidofovir, or imiquimod) for herpes infections that no longer respond to acyclovir. It involved 158 immunocompromised participants, such as those with HIV or organ transplants. The goal wa…

This study looked at 38 kidney transplant patients who had CMV infection. Researchers wanted to see if measuring a type of immune cell (γδ T cells) could help decide who needs extra medication to prevent the virus from coming back. The goal is to avoid unnecessary drugs while sti…

This study tested an experimental mRNA vaccine (mRNA-1608) in 303 healthy adults aged 18 to 55 with recurrent genital herpes caused by HSV-2. The goal was to see if the vaccine is safe and can reduce the number of outbreaks. Participants received different doses of the vaccine or…

This study tested two different medicines to prevent CMV infection in 70 kidney transplant patients at high risk. One group received the standard drug valganciclovir, while the other received maribavir plus acyclovir. The goal was to see which approach caused fewer side effects l…

This study looked at how well the shingles vaccine works and how safe it is for people living with HIV. Researchers compared the immune response based on participants' CD4+ T-cell counts and age. The goal was to provide evidence to help guide vaccination recommendations for this …

This study tested whether the antiviral drug valacyclovir (Valtrex) could slow brain changes linked to Alzheimer's in 50 people with mild cognitive impairment who also had herpes simplex virus antibodies. Participants took either valacyclovir or a placebo for 52 weeks. The goal w…

This early-stage study tested a new drug called ABI-5366 in 115 people to see if it is safe and how the body processes it. Part A involved healthy volunteers receiving a single dose, while Part B included people with recurrent genital herpes who received multiple doses. The goal …

This early study tests an experimental drug called ABI-1179 in healthy volunteers and people with recurrent genital herpes caused by HSV-2. The main goal is to check safety and how the body processes the drug. Researchers will give single or multiple doses and monitor for side ef…

This study tested whether an ultrasound-guided nerve block, using a steroid and local anesthetic, could better control pain from shingles and prevent postherpetic neuralgia (long-term nerve pain). 100 adults with acute shingles and moderate to severe pain were randomly assigned t…

This study tested a cream containing acyclovir and penciclovir against an over-the-counter cream (Abreva) for preventing cold sores caused by UV light. Forty adults with a history of cold sores were exposed to UV light to trigger an outbreak, then treated with one of the creams. …

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested whether EDTA eye drops can shorten cold sore outbreaks compared to the over-the-counter cream Abreva. Ten adults with a history of sun-triggered cold sores were randomly assigned to one of the two treatments. Researchers tracked how many days it took for each co…

This study tested whether the antiviral drug valacyclovir (Valtrex) can slow memory loss in people with mild Alzheimer's disease who also carry the herpes simplex virus. About 120 participants received either the drug or a placebo for 18 months. The goal was to see if treating th…

This study tested whether giving HIV-infected infants with severe pneumonia early treatment for cytomegalovirus (CMV) and tuberculosis (TB) could help them survive. Over 500 babies aged 1 month to 1 year were randomly assigned to receive either standard care or additional drugs f…

This study tested an experimental immunotherapy for herpes simplex virus (HSV) in 505 people. In the first part, healthy adults aged 18-40 received different vaccine-like formulations to check safety. In the second part, adults aged 18-60 with recurrent genital herpes got the tre…

This study tested whether giving the antiviral drug valacyclovir to pregnant women with a CMV-infected fetus could reduce the chance of the baby being born with serious symptoms. 41 pregnant women took high doses of valacyclovir daily for up to 23 weeks. The goal was to see if th…

This study tested whether giving patients special immune cells (T cells) that target CMV or adenovirus could control these infections after a stem cell transplant. Sixteen children and adults received one or two doses of these cells. The goal was to reduce virus levels in the blo…

This study compares three automated blood tests (Abbott Architect, Siemens Immulite, and Diasorin Liaison) for diagnosing Epstein-Barr virus (EBV) infection. Researchers analyzed 91 blood samples from patients aged 3 to 82 to see how well each test detects key markers of EBV infe…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study looked at whether newborns who fail their hearing screening can be diagnosed with congenital CMV infection and have a full hearing test before they turn one month old. Researchers tested 235 babies to see how quickly they could get results. The goal is to improve early…

This completed study tested whether an AI device could help 16 doctors (10 general practitioners and 6 dermatologists) more accurately diagnose 13 different skin conditions, including melanoma, psoriasis, and acne. The doctors reviewed 29 medical images, first giving a diagnosis …

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested a new blood test that looks for a tiny piece of the CMV virus's genetic material (a microRNA) in 60 patients who had a stem cell transplant. The goal was to see if this test could detect CMV reactivation earlier or more accurately than the standard DNA test. Res…

This study tested a new way to prevent CMV infection in 42 CMV-positive kidney transplant patients. Researchers combined an antibody infusion with a specific type of immune cell (gamma delta T cells) to see if it could stop the virus from reactivating. The goal was to find a safe…

This study tested the drug letermovir to prevent CMV infection in 15 adults who had a lung transplant for idiopathic pulmonary fibrosis (IPF). Participants took letermovir daily for 6 or 12 months depending on their CMV risk. The goal was to see if the drug could prevent CMV infe…

This study tested whether teaching pregnant women about CMV risks and protective behaviors could prevent them from catching the virus. 582 women were enrolled early in pregnancy. The intervention involved brief counseling sessions. The goal was to reduce CMV infections that can c…

This study tests whether teaching pregnant women about hygiene habits can reduce their risk of catching cytomegalovirus (CMV) and passing it to their baby. Researchers will enroll 200 pregnant women in Brazil and provide counseling on behaviors like handwashing. The goal is to cu…

This early-stage trial tested a vaginal insert containing two anti-HIV drugs (tenofovir alafenamide and elvitegravir) in 68 healthy women. The insert was used daily for 3 days then every other day for 14 days. The goal was to check safety and measure drug levels in the body, as a…

This study tested a single acyclovir tablet that sticks to the gum to treat cold sores (herpes labialis) in 2020 adults with frequent outbreaks. Participants applied the tablet or a placebo at home and tracked healing over 14 days. The goal was to see if the drug shortens the tim…

This study looked at 324 people with hearing loss and an inner ear problem called enlarged vestibular aqueducts. Researchers collected DNA, hearing tests, and scans to find genes that may cause the condition. The goal was to learn more about why it happens, not to test a treatmen…

This study looks at why certain immune cells (CD4 and CD8 T cells) remain activated in people with HIV whose viral load has been undetectable on antiretroviral therapy for at least two years. Researchers are investigating whether a common virus called cytomegalovirus (CMV) or an …

This study looked at whether a simple saliva test can find cytomegalovirus (CMV) in children aged 3 months to 6 years. Researchers collected saliva samples from 655 children in daycares and a hospital emergency department. The goal was to see how common the virus is and to check …

This study looked at 190 HIV-positive women starting HIV medicines to see how often herpes virus symptoms appear or get worse. Researchers collected blood, urine, and vaginal samples over a year to track virus activity. The goal was to understand why some women have herpes flare-…

This study looked at 236 kidney transplant patients to find out why some fail to develop immune protection against cytomegalovirus (CMV) in the first 45 days after surgery. Researchers reviewed medical records to compare patients who had a strong immune response with those who di…

This study looked at 800 children and adults who received a liver transplant in China to learn how often they get infected with cytomegalovirus (CMV), a common virus that can cause serious problems after transplant. Researchers tracked patients for one year, checking for CMV infe…

This study looked at how the drug letermovir passes from a pregnant woman to her fetus during the second trimester. Seven women who were already scheduled to end their pregnancy for other reasons took part. The goal was to measure drug levels in fetal blood and amniotic fluid to …

This Phase 1 study tested different doses of the oral antiviral drug valacyclovir in 17 newborns whose mothers had genital herpes. The goal was to find a dose that gives similar drug levels in the blood as the standard IV treatment. Researchers measured how the drug was processed…

This study looked at whether a blood test that measures immune response to CMV can predict infection risk in children who have received a heart, kidney, or liver transplant. Researchers tested blood samples from 161 children within the first year after transplant. The goal is to …

This completed study reviewed medical records of 50 obese adults with HSV encephalitis (a brain infection) to see how different ways of calculating acyclovir dose affect survival. Researchers looked at patients treated between 2013 and 2019 at six hospitals. The goal was to find …

This study looked at whether having patients collect a small blood sample at home (using a finger prick) and getting reminders on their phone could help them stick to weekly testing for cytomegalovirus (CMV) after a stem cell transplant. About 150 transplant recipients took part.…

This study looked at 139 children having a colonoscopy to see how often the CMV virus is found in their gut tissue and blood. Some children had inflammatory bowel disease (Crohn's or colitis) and some did not. The goal was to learn which tests best detect CMV in the gut, helping …

This study looked at health records of nearly 69,000 adults aged 40 and older to see if those who develop lasting nerve pain after shingles (postherpetic neuralgia) have a higher chance of getting dementia later. Researchers compared people with and without this nerve pain, match…

This study followed 187 melanoma patients treated with IMLYGIC, a modified herpes virus that attacks cancer cells. Researchers tracked whether the virus spread to patients' close contacts or healthcare providers, and monitored long-term safety for up to 5 years. The goal was to u…

This study reviewed medical records of 330 kidney transplant patients in the UK to understand how cytomegalovirus (CMV) infections are managed. Researchers looked at how common these infections are, what treatments were used, and how well they worked. The goal was to gather infor…

This study looked at how many medical students have immunity against hepatitis B and varicella-zoster (chickenpox) viruses. Researchers tested 401 students to see their protection levels and vaccination rates. The goal was to understand if current immunization programs are workin…

This study followed 400 stem cell transplant recipients to see how well anti-CMV medications work in everyday hospital care. Researchers tracked infections, drug resistance, and side effects. The goal was to gather real-life data to improve treatment guidelines for these high-ris…

This study looked at 151 adults with shingles to find clues that might predict who will develop lasting nerve pain (postherpetic neuralgia). Researchers collected blood samples and health information at the start and checked for pain three months later. The goal was to create a r…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This study tested whether saliva samples can be used to remotely monitor cytomegalovirus (CMV) infection in people receiving treatment for ovarian cancer. Researchers compared saliva and blood samples from 49 participants, collected either at the clinic or at home. The goal was t…

This completed study examined 110 people with radiologically isolated syndrome (RIS) — a condition where brain scans show signs that could lead to multiple sclerosis (MS). Researchers looked at whether past Epstein-Barr virus infection and low vitamin D levels are linked to a hig…

This study followed 509 kidney transplant recipients to see if regularly measuring Epstein-Barr virus (EBV) levels in blood could predict serious infections, a type of cancer called PTLD, or death. Researchers compared virus levels in whole blood versus plasma to find the best wa…

This study looked at 30 people with shingles (herpes zoster) to measure levels of inflammatory proteins and nerve-related chemicals in their blood. Researchers wanted to understand how these substances change over time and relate to pain. The study did not test any new treatment,…

This study looked at 254 newborns with congenital cytomegalovirus (CMV) infection to find early signs that predict hearing loss or other brain-related problems at age 1. Researchers used clinical exams, brain scans, and lab tests to build a scoring system. The goal is to help doc…