New hope for Drug-Resistant herpes in vulnerable patients

NCT ID NCT03073967

Completed Disease control Sponsor: AiCuris Anti-infective Cures AG Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new oral drug called pritelivir against standard treatments (foscarnet, cidofovir, or imiquimod) for herpes infections that no longer respond to acyclovir. It involved 158 immunocompromised participants, such as those with HIV or organ transplants. The goal was to see if pritelivir could heal lesions faster and more safely.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pritelivir (oral tablet)
What this could lead to: If it works, this could provide a new treatment option for people with weakened immune systems who have herpes infections that don't respond to standard acyclovir therapy.
What could go wrong: This is a completed Phase 3 trial, but results are not yet widely available. The drug may not prove superior to existing treatments like foscarnet or cidofovir, which have their own side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

herpes simplex infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HSV INFECTION

Contacts and locations

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Locations

AP-HP Hopital Bichat - Claude Bernard

Paris, 75018, France
AP-HP Hopital Necker-Enfants Malades

Paris, 75015, France
ARENSIA Exploratory Medicine LLC

Kyiv, 01135, Ukraine
AZ Delta

Roeselare, 8800, Belgium
AZ Sint-Jan Brugge

Bruges, 8000, Belgium
Alberta Health Services Cross Cancer Institute at the University of Alberta

Edmonton, Alberta, T6G 1Z2, Canada
Arke SMO S.A. de C.V.

Veracruz, 91910, Mexico
Atrium Health Wake Forest Baptist

Winston-Salem, North Carolina, 27157, United States
Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States
CHU Limoges - Centre national de reference des Herpes virus

Limoges, 87042, France
CHU de Nantes

Nantes, 44093, France
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Centre Hospitalier Universitaire Saint Pierre

Brussels, B1000, Belgium
Centro de Investigacion Clinica GRAMEL S.C.

Distrito Federal, 03720, Mexico
Centro de Investigacion Farmaceutica Especializado de Occidente S.C.

Guadalajara, 44160, Mexico
Chaim Sheba Medical Center

Tel Litwinsky, 5265601, Israel
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
City of Hope

Duarte, California, 91010, United States
David H. Koch Center at Memorial Sloan Kettering Cancer Center

New York, New York, 10021, United States
Department of Medicine J. H. Stroger Hospital of Cook County

Chicago, Illinois, 60612, United States
Duke University Medical Center - Division of Infectious Diseases

Durham, North Carolina, 27710, United States
Emory Hospital Midtown Infectious Disease Clinic

Atlanta, Georgia, 30308, United States
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano

Milan, 20122, Italy
Fondazione IRCCS Policlinico San Matteo

Pavia, 27100, Italy
Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States
Freeman Hospital

Newcastle upon Tyne, NE7 7DN, United Kingdom
General Hospital of Athens - Laiko

Athens, 11527, Greece
Grande Ospedale Metropolitano "Bianchi Melacrino Morelli"

Calabria, 89133, Italy
Hopitaux universitaires de Geneve

Geneva, 1205, Switzerland
Hospital Rawson

Córdoba, 5000, Argentina
Hôpital Saint Louis - AP-HP

Paris, 75010, France
Instituto FIDES

La Plata, CP 1900, Argentina
Instituto de Investigaciones Aplicadas a la Neurociencia A.C

Durango, 34000, Mexico
Johns Hopkins University School of Medicine

Baltimore, Maryland, 21205, United States
Kings Country Hospital Center

Brooklyn, New York, 11203, United States
LLC Diakor

Tbilisi, 0159, Georgia
LSU Health Baton Rouge Pulmonary Clinic

Baton Rouge, Louisiana, 70809, United States
Lee's Summit MO United States 64086

Lee's Summit, Missouri, 64086, United States
Links Clinical Trials

Miami, Florida, 33176, United States
MD Anderson Cancer Center

Houston, Texas, 77030-4009, United States
Melbourne Health - Royal Melbourne Hospital

Parkville, 3050, Australia
Metro Infectious Disease Consultants - Atlanta

Decatur, Georgia, 30033, United States
Metro Infectious Disease Consultants, LLC

Burr Ridge, Illinois, 60527, United States
Metro Infectious Disease Consultants, LLC - Huntsville

Huntsville, Alabama, 35801, United States
Midland Florida Clinical Research Center, LLC

DeLand, Florida, 32720, United States
Midway Immunology and Research Center (MIRC)

Ft. Pierce, Florida, 34982, United States
Multiprofile Clinic Consilium Medulla LTD

Tbilisi, 0186, Georgia
Nhs Lothian

Edinburgh, EH4 2XU, United Kingdom
Penn State Health Milton S. Hershey Medical Center

Hershey, Pennsylvania, 17033, United States
Regional University General Hospital of Heraklion

Heraklion, 71110, Greece
Research Department of Haematology, UCL Cancer Institute

London, WC1E 6BT, United Kingdom
Rutgers Robert Wood Johnson Medical School

New Brunswick, New Jersey, 08901, United States
Sanatorio Mayo Privado S.A.

Córdoba, 5000, Argentina
Tulane University - School of Medicine

New Orleans, Louisiana, 70112, United States
Unidad de Investigacion CIMA SC

Chihuahua City, 64718, Mexico
Universitaetsspital Basel

Basel, 4031, Switzerland
Universitaetsspital Zuerich

Zurich, 8091, Switzerland
University Arizona - Department of Medicine Arizona Health Sciences Center

Tucson, Arizona, 85724, United States
University of Alabama at Birmingham

Birmingham, Alabama, 35205, United States
University of California, Division of Infectious Diseases

Sacramento, California, 95817, United States
University of Florida (UF) - Division of Infectious Disease

Gainesville, Florida, 32610, United States
University of Minnesota

Minneapolis, Minnesota, 55455, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15232, United States
University of South Alabama

Mobile, Alabama, 36604, United States
University of South Florida

Tampa, Florida, 33606, United States
Universitätsklinikum Essen

Essen, 45147, Germany
Universitätsklinikum Köln

Cologne, 50937, Germany
Universitätsklinikum Würzburg

Würzburg, 97080, Germany
Westmead Hospital, Centre for Infectious Disease and Microbiology

Westmead, 2145, Australia