New mRNA vaccine shows promise against common virus that can harm newborns
NCT ID NCT04232280
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested an experimental mRNA vaccine called mRNA-1647 to see if it is safe and triggers an immune response against cytomegalovirus (CMV). The trial involved 315 healthy adults aged 18 to 40, some of whom had never been exposed to CMV. Researchers measured side effects and antibody levels after vaccination. The goal is to develop a vaccine that could prevent CMV infection, which can cause serious problems in newborns and people with weak immune systems.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mRNA-1647 vaccine
What this could lead to
If successful, this vaccine could help prevent cytomegalovirus infection, which is a leading cause of birth defects and complications in people with weakened immune systems.
What could go wrong
This is an early phase 2 trial with only 315 participants, so the vaccine may not work as well in larger, more diverse populations. Side effects like injection site pain, headache, and fatigue were common.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Alliance for Multispecialty Research
Lexington, Kentucky, 40509, United States
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Aventiv Research Inc
Columbus, Ohio, 43213-6523, United States
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Benchmark Research
Sacramento, California, 95864, United States
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Crossroads Clinical Research
Victoria, Texas, 77901, United States
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Foothill Family Clinic
Salt Lake City, Utah, 84109, United States
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Foothill Family Clinic-South Clinic
Salt Lake City, Utah, 84121, United States
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Johnson County Clin-Trials
Lenexa, Kansas, 66219, United States
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Optimal Research
Peoria, Illinois, 61614, United States
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Tekton Research Inc
Austin, Texas, 78745, United States