Modernatx, Inc.

This study tests an experimental mRNA vaccine (mRNA-1018-H5) designed to protect against a potential H5N1 bird flu pandemic. About 4,000 healthy adults aged 18 and older will receive two doses of the vaccine or a placebo. Researchers will measure how well the vaccine triggers an …

This early-stage study is testing a new mRNA vaccine called mRNA-1189 to see if it is safe and can protect against Epstein-Barr virus (EBV). About 120 healthy adults aged 18 to 30 will receive the vaccine either under the skin or into a muscle. Researchers will monitor side effec…

This study tests several updated mRNA COVID-19 vaccines designed to protect against new variants of the virus. About 1,144 adults and children who have been previously vaccinated will receive one of the new vaccine formulas. Researchers will measure how well the vaccines boost th…

This study tests an updated COVID-19 vaccine (mRNA-1283) designed to protect against current virus variants. About 832 people aged 12 and older, especially those at higher risk, will receive the vaccine. Researchers will measure immune response and monitor for side effects to ens…

This study tests an experimental mRNA vaccine (mRNA-1982) designed to prevent Lyme disease, which is spread by tick bites. About 350 healthy adults aged 18 to 70 will receive either the vaccine or a placebo to check for safety and immune response. The goal is to find the best dos…

This study looks at the long-term safety of an experimental medicine called mRNA-3927 for people with propionic acidemia, a rare genetic disorder that prevents the body from breaking down certain proteins and fats. About 50 participants who were in an earlier study will continue …

This study tests an experimental mRNA treatment, mRNA-4359, in people with advanced solid tumors that have not responded to standard therapies. The treatment is given alone or with other immune-boosting drugs. The main goals are to check safety and find the best dose. About 361 a…

This study tests an experimental mRNA medicine called mRNA-1195 in 180 adults aged 18 to 55 who have multiple sclerosis (MS). The goal is to see if it is safe and can reduce brain lesions linked to MS activity. Participants will receive either the study drug or a placebo injectio…

This study tests a new mRNA treatment, mRNA-2808, in people with multiple myeloma that has come back or stopped responding to other therapies. The goal is to see if it is safe and how well it controls the cancer. About 166 participants will receive the treatment, and researchers …

This study is for people with methylmalonic acidemia (MMA) who have already taken part in earlier studies of the experimental drug mRNA-3705. The goal is to see if the drug is safe and works well over a longer period. About 56 participants will receive the treatment and be monito…

This study tests an experimental mRNA therapy called mRNA-3927 for people with propionic acidemia, a rare genetic disorder that prevents the body from breaking down certain proteins and fats, leading to dangerous metabolic crises. The trial includes children and adults, with a se…

This study looks at medical records of 60 people with propionic acidemia, a rare genetic disorder. Researchers want to count how often patients have serious metabolic events and need hospital care. No new treatment is given—the goal is to better understand the disease.