New mRNA shot targets bird flu: 4,000 volunteers needed

NCT ID NCT07496450

Ongoing ⭐️ VACCINE ⭐️ Sponsor: ModernaTX, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 12, 2026 · Updated 3 times

Summary

This large phase 3 trial is testing an experimental mRNA vaccine (mRNA-1018-H5) designed to protect against H5N1 pandemic influenza. Around 4,000 healthy adults aged 18 and older will receive two doses of the vaccine or a placebo. Researchers will measure immune responses and monitor for side effects to see if the vaccine is safe and effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mRNA-1018-H5 vaccine
What this could lead to: If successful, this could provide a safe and effective vaccine to protect against a future H5N1 bird flu pandemic.
What could go wrong: This is still an experimental vaccine. Even if it triggers an immune response, it may not prevent infection in the real world, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

avian influenza viral infectious disease influenza prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFLUENZA

Contacts and locations

Locations

Accellacare North London

Northwood, Greater London, HA6 2RN, United Kingdom
Accellacare South London

Orpington, Greater London, BR5 3QG, United Kingdom
Accellacare Warwickshire

Coventry, West Midlands (Coventry), CV3 4FJ, United Kingdom
Accellacare Yorkshire

Shipley, West Yorkshire, BD18 3SA, United Kingdom
FutureMeds Birmingham Soho Road Health Centre

Birmingham, West Midlands, B21 9RY, United Kingdom
FutureMeds Liverpool

Metropolitan Borough of Wirral, Merseyside, CH62 6EE, United Kingdom
Futuremeds Teesside Middlefield Centre University Hospital of North Tees

Stockton-on-Tees, County Durham, TS19 8PE, United Kingdom
Fylde Coast Clinical Research at Layton Medical Centre

Blackpool, Lancashire, FY3 7EN, United Kingdom
Hounslow Medical Centre

Hounslow, Greater London, TW3 3ET, United Kingdom
Lakeside Healthcare

Corby, North Northamptonshire, NN17 2UR, United Kingdom
NIHR Wessex CRDC - Bournemouth Research Hub (Under University Hospital Southampton NHS Foundation Trust)

Bournemouth, Dorset, BH7 7DW, United Kingdom
NIHR Wessex CRDC - Southampton Research Hub (Under University Hospital Southampton NHS FT)

Southampton, Hampshire, SO15 3UA, United Kingdom
NIHR Wessex CRDC - Weymouth Research Hub (Under University Hospital Southampton NHS Foundation Trust)

Weymouth, Dorset, DT4 0QE, United Kingdom
Panthera Enfield

Enfield, Greater London, EN3 4GS, United Kingdom
Panthera Glasgow

Glasgow, Glasgow City (Scotland), G51 4TF, United Kingdom
Panthera Rochdale

Rochdale, Greater Manchester, OL11 4AU, United Kingdom
Panthera Sheffield

Sheffield, South Yorkshire, S2 5FX, United Kingdom
Panthera York

York, North Yorkshire, YO24 4LJ, United Kingdom
The University of Nottingham Health Service

Nottingham, Nottinghamshire, NG7 2QW, United Kingdom
Velocity Clinical Research - High Wycombe

High Wycombe, Buckinghamshire, HP11 2QW, United Kingdom
Velocity Clinical Research, Anderson

Anderson, South Carolina, 29621, United States
Velocity Clinical Research, Boise

Meridian, Idaho, 83642, United States
Velocity Clinical Research, Cleveland

Beachwood, Ohio, 44122, United States
Velocity Clinical Research, Dallas

Dallas, Texas, 75230, United States
Velocity Clinical Research, Omaha

Omaha, Nebraska, 68134, United States
Velocity Clinical Research, Providence

East Greenwich, Rhode Island, 02818, United States
Velocity Clinical Research, Rockville

Rockville, Maryland, 20854, United States
Velocity Clinical Research, San Bernardino

San Bernardino, California, 92408, United States
Velocity Clinical Research, Savannah

Savannah, Georgia, 31406, United States
Velocity Clinical Research, Suffolk

Suffolk, Virginia, 23435, United States
Velocity Clinical Research-Bristol

Bristol, Bristol (Unitary Authority), BS8 2RA, United Kingdom
Velocity Clinical Research-North London

London, Greater London, N12 8BU, United Kingdom
Velocity Clinical Research-Romford

Romford, Greater London, RM1 3PJ, United Kingdom
Wansford Research Ltd

Peterborough, Cambridgeshire, PE8 6PL, United Kingdom
hVIVO Services Limited

London, Greater London, E1 1EQ, United Kingdom

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