New blood test may help protect kids from post-transplant infection

NCT ID NCT03924219

Completed Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether a blood test that measures immune response to CMV can predict infection risk in children who have received a heart, kidney, or liver transplant. Researchers tested blood samples from 161 children within the first year after transplant. The goal is to find immune response levels that indicate protection, which could help doctors decide how long to give antiviral drugs or how often to monitor for infection.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CMV T cell Immunity Assay (blood test)
What this could lead to: If successful, this test could help doctors personalize antiviral treatment for children after transplant, reducing unnecessary medication and preventing infections.
What could go wrong: This is an observational study, not a treatment trial. The test may not accurately predict infection risk in all children, and results may not change current care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cytomegalovirus infection pyelonephritis renal infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CMV HEART TRANSPLANT INFECTION KIDNEY TRANSPLANT INFECTION LIVER TRANSPLANT INFECTION

Contacts and locations

Locations

Albert Einstein College of Medicine/Children's Hospital at Montefiore

New York, New York, 10467, United States
Boston Children's Hospital

Boston, Massachusetts, 02115, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children's Mercy Hospital

Kansas City, Missouri, 64108, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Duke University Medical Center/Duke Children's Hosptial

Durham, North Carolina, 27710, United States
Emory University Medical Center/Children's Hospital of Atlanta

Atlanta, Georgia, 30322, United States
Northwestern University Medical Center/Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611, United States
Stanford University Medical Center/Lucile Packard Children's Hospital Stanford

Stanford, California, 94305, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of Pittsburgh Medical Center/Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, 15224, United States
Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

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