Supercharged immune cells take on Hard-to-Treat lymphoma

NCT ID NCT04664179

Recruiting now Disease control Sponsor: Baylor College of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tests a new type of immune cell therapy for patients with EBV-positive Hodgkin or non-Hodgkin lymphoma that has returned or not responded to standard treatments. The researchers add a gene called C7R to the patient's own T cells to help them survive longer in the body, potentially improving their ability to kill cancer cells. The study aims to find the safest dose and see if the cells can shrink tumors.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: C7R-modified EBV-specific T cells
What this could lead to: If it works, this could offer a new treatment option for patients with EBV-positive lymphoma that has not responded to standard therapies.
What could go wrong: This is a very early phase 1 trial with only 52 participants, so it is too soon to know if the approach is safe or effective. There are risks of serious side effects from the modified T cells.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell non-Hodgkin lymphoma Epstein-Barr virus infection Epstein-Barr virus-associated lymphoproliferative disorder Hodgkins lymphoma non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

Baylor St. Luke's Medical Center
NOT_YET_RECRUITING

Houston, Texas, 77054, United States
Harris Health System - Ben Taub General Hospital/Smith Clinic
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
Texas Children's Hospital
NOT_YET_RECRUITING

Houston, Texas, 77030, United States

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