New immune cells take aim at Virus-Linked lymphomas

NCT ID NCT01555892

Recruiting now Disease control Sponsor: Baylor College of Medicine Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new way to make immune cells (called GRALE T cells) that are trained to attack cells infected with the Epstein-Barr virus (EBV), which is linked to some lymphomas. The trial includes people with Hodgkin or non-Hodgkin lymphoma, or related diseases, whose cancer has returned or not gone away. The goal is to find a safe dose and see if these cells can survive in the body and fight the tumor.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: GRALE T cells (immune cells trained to attack EBV-infected cells)
What this could lead to: If it works, this could offer a new treatment option for patients with EBV-related lymphomas that have not responded to standard therapy.
What could go wrong: This is an early phase 1 trial, so the main goal is safety, not yet proof of effectiveness. The treatment is experimental and may not shrink tumors or could cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

B-cell non-Hodgkin lymphoma classic Hodgkin lymphoma Epstein-Barr virus-associated lymphoproliferative disorder Hodgkins lymphoma immunodeficiency 32B lymphoma lymphoproliferative disease, dog lymphoproliferative syndrome non-Hodgkin lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HODGKIN'S DISEASE LYMPHOMA LYMPHOPROLIFERATIVE DISEASE NON-HODGKIN'S LYMPHOMA

Contacts and locations

Locations

Harris Health System (includes ben Taub General Hospital and Smith)
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Houston Methodist Hospital
RECRUITING

Houston, Texas, 77030, United States
Texas Children's Hospital
RECRUITING

Houston, Texas, 77030, United States

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