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Could a cold sore virus treatment save ICU pneumonia patients?

NCT ID NCT06134492

Recruiting now Disease control Sponsor: Jena University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This study tests whether the antiviral drug acyclovir helps people on breathing machines who have pneumonia and also have herpes simplex virus (HSV) in their lungs. About 616 adults in intensive care will be randomly assigned to receive acyclovir or no antiviral treatment. The goal is to see if treating the virus improves survival, since current evidence is unclear and acyclovir can cause kidney side effects.

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Conditions

The condition(s) this trial relates to.

Community-Acquired Pneumonia Healthcare-Associated Pneumonia herpes simplex infectious disease nosocomial infection pneumonia Pneumonia, Ventilator-Associated viral pneumonia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMMUNITY-ACQUIRED PNEUMONIA HERPES SIMPLEX HOSPITAL-ACQUIRED PNEUMONIA PNEUMONIA, VIRAL VENTILATOR ASSOCIATED PNEUMONIA

Contacts and locations

Locations

  • Evangelisches Klinikum Bethel

    RECRUITING

    Bielefeld, North Rhine-Westphalia, 33617, Germany

  • Evangelisches Klinikum Bethel

    RECRUITING

    Bielefeld, 33611, Germany

  • Klinikum Nürnberg, Campus Nord

    RECRUITING

    Nuremberg, Bavaria, 90419, Germany

  • Klinikum Nürnberg, Campus Süd

    RECRUITING

    Nuremberg, Bavaria, 90471, Germany

  • Klinikum der Ludwig-Maximilian-Universität München

    RECRUITING

    München, Bavaria, 81377, Germany

  • Klinikum rechts der Isar

    RECRUITING

    München, Bavaria, 81675, Germany

  • Klinikum rechts der Isar

    RECRUITING

    München, Bavaria, 81675, Germany

  • Marien Hospital Herne, Universitätsklinikum der Ruhr-Universität Bochum

    RECRUITING

    Herne, Nordreihn-Westfalen, 44625, Germany

  • RoMed Klinikum Rosenheim

    RECRUITING

    Rosenheim, Bavaria, 83022, Germany

  • Universitätsklinikum Augsburg

    RECRUITING

    Augsburg, Bavaria, 86156, Germany

  • Universitätsklinikum Bonn

    RECRUITING

    Bonn, North Rhine-Westphalia, 53127, Germany

  • Universitätsklinikum Dresden

    RECRUITING

    Dresden, Saxony, 01307, Germany

  • Universitätsklinikum Düsseldorf

    RECRUITING

    Düsseldorf, North Rhine-Westphalia, 40225, Germany

  • Universitätsklinikum Essen

    RECRUITING

    Essen, North Rhine-Westphalia, 45147, Germany

  • Universitätsklinikum Freiburg

    RECRUITING

    Freiburg im Breisgau, Baden-Wurttemberg, 79106, Germany

  • Universitätsklinikum Halle

    RECRUITING

    Halle, Saxony-Anhalt, 06120, Germany

  • Universitätsklinikum Hamburg Eppendorf

    RECRUITING

    Hamburg, Free and Hanseatic City of Hamburg, 20246, Germany

  • Universitätsklinikum Heidelberg

    RECRUITING

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • Universitätsklinikum Heidelberg

    RECRUITING

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • Universitätsklinikum Jena

    RECRUITING

    Jena, Thuringia, 07747, Germany

  • Universitätsklinikum Köln AöR

    RECRUITING

    Cologne, North Rhine-Westphalia, 50937, Germany

  • Universitätsklinikum Leipzig

    RECRUITING

    Leipzig, Saxony, 04103, Germany

  • Universitätsklinikum Leipzig

    RECRUITING

    Leipzig, Saxony, 04103, Germany

  • Universitätsklinikum Münster

    RECRUITING

    Münster, North Rhine-Westphalia, 48149, Germany

  • Universitätsklinikum Regensburg

    RECRUITING

    Regensburg, Bavaria, 93053, Germany

  • Universitätsklinikum Schleswig-Holstein Campus Kiel

    RECRUITING

    Kiel, Schleswig-Holstein, 24105, Germany

  • Universitätsklinikum Schleswig-Holstein Campus Lübeck

    RECRUITING

    Lübeck, Schleswig-Holstein, 23538, Germany

  • Universitätsklinikum Tübingen

    RECRUITING

    Tübingen, Baden-Wurttemberg, 72076, Germany

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