VENTILATOR ASSOCIATED PNEUMONIA

This study looks at whether treating herpes simplex virus (HSV) with acyclovir helps people on breathing machines who have pneumonia. Almost half of these patients have HSV in their lungs, but it's unclear if treating it improves survival. The trial will randomly assign 616 parti…

This study tests whether adding the steroid hydrocortisone to standard treatment helps ICU patients with severe hospital-acquired pneumonia. Researchers will compare hydrocortisone to a placebo in 180 adults to see if it reduces death, breathing failure, or heart problems. The dr…

This study looks at whether a blood test called reticulated platelet fraction (RP%) can help doctors diagnose ventilator-associated pneumonia (VAP) earlier and predict how well patients will do. About 42 adults in the ICU who are on breathing machines will have their blood tested…

This study tests whether giving probiotics (good bacteria) to intensive care patients on breathing machines can prevent a serious lung infection called ventilator-associated pneumonia. The trial will enroll 186 adults with head injuries, strokes, or brain bleeds who are on ventil…

This study looks at how certain white blood cells (macrophages) in the lungs react to inflammation in people with Acute Respiratory Distress Syndrome (ARDS). Researchers want to understand how these cells help turn off inflammation and repair lung damage. Participants are adults …

This study is observing 1,000 adults in the intensive care unit (ICU) to learn more about why some people get very sick from infections or injuries. Researchers will collect blood samples and health data to find early signs that could help diagnose serious conditions like sepsis …