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Could probiotics stop ventilator pneumonia? new trial aims to find out

NCT ID NCT06092554

Recruiting now Prevention Sponsor: University of Bari Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether giving probiotics (LactoLevure) to ICU patients on ventilators can prevent ventilator-associated pneumonia. The trial will enroll 186 adults with head injury, stroke, or brain hemorrhage. Patients receive probiotic or placebo capsules twice daily for 30 days. The goal is to see if probiotics reduce infection rates and deaths.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Probiotics (LactoLevure)
What this could lead to
If it works, this could provide a simple, low-cost way to prevent lung infections in ICU patients on ventilators.
What could go wrong
This is a relatively small, early-stage trial. Probiotics may not reduce infection rates, and results may not apply to all ICU patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic intracerebral hemorrhage Pneumonia, Ventilator-Associated stroke disorder traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

VENTILATOR ASSOCIATED PNEUMONIA

Contacts and locations

Locations

  • AUSL Bologna Ospedale Bellaria

    RECRUITING

    Parma, Italy

  • Azienda Ospedaliera di Perugia

    RECRUITING

    Perugia, Italy

  • Azienda Ospedaliero Universitaria di Alessandria SS. Antonio e Biagio e Cesare Arrigo

    RECRUITING

    Alessandria, Italy

  • Azienda Ospedaliero Universitaria di Parma

    RECRUITING

    Parma, Italy

  • Azienda ospedaliera Santa Maria di Terni

    RECRUITING

    Terni, Italy

  • Hospital Erasme

    RECRUITING

    Brussels, Belgium

  • Intensive Care Unit, Policlinico di Bari

    RECRUITING

    Bari, BA, Italy

  • Ospedale Di Venere

    RECRUITING

    Bari, 70131, Italy

  • Regional General Hospital F. Miulli

    RECRUITING

    Acquaviva delle Fonti, BA, Italy

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