Can a two-drug combo beat the HTLV-1 virus?
NCT ID NCT07555431
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial compares the drug dolutegravir alone versus dolutegravir combined with tenofovir in 146 adults with HTLV-1 infection and related symptoms. The main goal is to see if the combination lowers the virus level more effectively and improves pain, spasticity, and muscle strength over 48 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
dolutegravir and tenofovir disoproxil fumarate
What this could lead to
If successful, this could point toward a more effective treatment to lower the virus and ease symptoms like pain and muscle weakness in people with HTLV-1.
What could go wrong
This is a small, early-phase trial (Phase 2) with only 146 participants. The combination has not been tested before, so it may not work better than dolutegravir alone, and side effects are not yet well understood.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Hospital Universitário Professor Edgard Santos
RECRUITINGSalvador, Estado de Bahia, 40110-060, Brazil
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••