Pregnant women with hepatitis c get new hope in drug trial

NCT ID NCT07040319

Recruiting now Disease control Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Aug 14, 2026 · Updated 4 times

Summary

This study is testing the safety and drug levels of glecaprevir/pibrentasvir, a hepatitis C treatment, in 30 pregnant women with or without HIV. The goal is to see how the drug works during pregnancy and to monitor the health of both mothers and their infants up to 10 weeks after birth. It is an early-phase trial, so results will help guide future treatment options.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: glecaprevir/pibrentasvir (a combination antiviral drug)
What this could lead to: If successful, this could provide a safe way to treat hepatitis C during pregnancy, potentially preventing mother-to-child transmission and improving outcomes for both mother and baby.
What could go wrong: This is an early-phase study with only 30 participants, so results may not apply to all pregnant women. There are also unknown risks to the fetus and infant, and the treatment may not work as well in those with HIV.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hepatitis C virus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEPATITIS C

Contacts and locations

Locations

Baylor College of Medicine//Texas Children's Hospital
RECRUITING

Houston, Texas, 77030, United States
Bronx-Lebanon Hospital Center
RECRUITING

The Bronx, New York, 10457, United States
David Geffen School of Medicine at UCLA
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
Jacobi Medical Center
NOT_YET_RECRUITING

The Bronx, New York, 10461, United States
Johns Hopkins University Baltimore
RECRUITING

Baltimore, Maryland, 21287, United States
Lurie Children's Hospital of Chicago
RECRUITING

Chicago, Illinois, 60614, United States
SUNY Stony Brook
RECRUITING

Stony Brook, New York, 11794, United States
USC LA
RECRUITING

Los Angeles, California, 90089, United States
Univ. of Florida Jacksonville
RECRUITING

Jacksonville, Florida, 32209, United States
University of Colorado Denver
RECRUITING

Aurora, Colorado, 80045, United States

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