New study aims to unlock why infections hit mitochondrial disease patients hard

NCT ID NCT04419870

Recruiting now Knowledge-focused Sponsor: National Human Genome Research Institute (NHGRI) Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jul 23, 2026 · Updated 3 times

Summary

This study follows 400 people with mitochondrial disease and their household members to learn how infections affect them. Researchers will analyze blood samples and health records to find immune patterns linked to severe illness. The goal is to improve care and identify potential targets for future treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help doctors better predict and manage severe infections in people with mitochondrial disease.
What could go wrong: This is an observational study, not a treatment trial. It may not lead to direct therapies, and results may take years to apply.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

inborn mitochondrial metabolism disorder mitochondrial disease viral infectious disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MITOCHONDRIAL DISEASE

Contacts and locations

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

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