Can an antioxidant boost brain health in mitochondrial disease?
NCT ID NCT05241262
First seen Jan 25, 2026 · Last updated May 12, 2026 · Updated 14 times
Summary
This early-stage study tests whether N-acetylcysteine (NAC), an antioxidant, can safely increase brain glutathione levels in people with a specific mitochondrial DNA mutation (m.3243A>G). 18 adults with low brain glutathione will receive one of three daily doses (1800, 3600, or 5400 mg) for 3 months. The main goal is to find the safest and most effective dose for future trials, while also checking effects on thinking, movement, and quality of life.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for MITOCHONDRIAL DISEASE are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10032, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Conditions
Explore the condition pages connected to this study.