New mRNA vaccine against mpox enters key trial in africa

NCT ID NCT07379580

Recruiting now ⭐️ VACCINE ⭐️ Sponsor: BioNTech SE Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 12, 2026 · Updated 7 times

Summary

This study tests an experimental mRNA vaccine called BNT166a to see if it is safe and can protect against mpox (monkeypox). About 310 healthy adults in Africa will receive either the vaccine or a placebo. The trial is double-blind, meaning neither participants nor doctors know who gets what. Researchers will monitor side effects and measure immune responses.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BNT166a (mRNA vaccine)
What this could lead to: If successful, this could lead to a safe and effective vaccine to prevent mpox (monkeypox) and related orthopoxvirus infections.
What could go wrong: This is a Phase 2 trial with only 310 participants, so it is still early. The vaccine may cause side effects like pain or fever, and it may not provide strong enough immunity to prevent infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

human infection by orthopoxvirus milker's nodule smallpox monkeypox prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MPOX (MONKEYPOX) ORTHOPOXVIRUS INFECTION SMALLPOX

Contacts and locations

Locations

Desmond Tutu Health Foundation Masiphumelele Clinic
RECRUITING

Cape Town, 7975, South Africa
Institute National de Recherche Biomedicale
RECRUITING

Kinshasa, 5345, Democratic Republic of the Congo
Perinatal HIV Research Unit
RECRUITING

Johannesburg, 1864, South Africa
TASK Applied Science
RECRUITING

Cape Town, 7405, South Africa
TREAD Research Pty Ltd
RECRUITING

Cape Town, 7530, South Africa
University of Kinshasa UNIKIN
RECRUITING

Kinshasa, 01306, Democratic Republic of the Congo

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