Does a smallpox drug weaken the vaccine? new study aims to find out.
NCT ID NCT04957485
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether taking the smallpox drug TPOXX changes how well the JYNNEOS vaccine works. About 100 healthy adults aged 18 to 42 will get two doses of the vaccine and either TPOXX or a placebo for 28 days. Researchers will check for side effects and measure immune response to see if the drug interferes with the vaccine.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Aventiv Research Inc
Columbus, Ohio, 43213-6510, United States
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Meridian Clinical Research
Omaha, Nebraska, 68134-3664, United States
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