Does a smallpox drug weaken the vaccine? new study aims to find out.
NCT ID NCT04957485
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether taking the smallpox drug TPOXX changes how well the JYNNEOS vaccine works. About 100 healthy adults aged 18 to 42 will get two doses of the vaccine and either TPOXX or a placebo for 28 days. Researchers will check for side effects and measure immune response to see if the drug interferes with the vaccine.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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Locations
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Aventiv Research Inc
Columbus, Ohio, 43213-6510, United States
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Meridian Clinical Research
Omaha, Nebraska, 68134-3664, United States