Supercharged immune cells take on Drug-Resistant infections
NCT ID NCT03159364
First seen Jun 27, 2026 ยท Last updated Jun 27, 2026
Summary
This trial investigates whether specially grown immune cells, called pathogen-specific cytotoxic T lymphocytes (CTLs), can safely and effectively treat stubborn infections like EBV, CMV, and adenovirus in people with weakened immune systems, such as stem cell or organ transplant recipients. Participants receive one or more infusions of these cells, which are designed to target and kill infected cells. The study aims to see if this approach can reduce viral levels and control infections when standard drugs have failed or cannot be used.
What this could mean
Our plain-language read of the trial. This is informational only โ not medical advice or a prediction.
- Active substance
- pathogen-specific cytotoxic T lymphocytes (CTLs)
- What this could lead to
- If it works, this approach could offer a new way to control serious infections in people with weak immune systems, especially when standard drugs fail.
- What could go wrong
- This is an early-phase trial, so the treatment may not work or could cause side effects like infusion reactions or graft-versus-host-like symptoms.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ADENOVIRUS INFECTION are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Shenzhen Geno-immune Medical Institute
RECRUITINGShenzhen, Guangdong, 518000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can cord blood t cells be trained to stop viral infections after transplant?
- Can immune profiling unlock the hidden stages of tuberculosis?
- Could inhaled TB drugs curb the spread of Drug-Resistant tuberculosis?
- Can new tests predict who will develop active TB?
- Could a 3-Month TB cocktail replace the standard 6-Month regimen?
- Could a simple blood test ensure the right TB dose for kids?