Supercharged immune cells take on Drug-Resistant infections

NCT ID NCT03159364

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This trial investigates whether specially grown immune cells, called pathogen-specific cytotoxic T lymphocytes (CTLs), can safely and effectively treat stubborn infections like EBV, CMV, and adenovirus in people with weakened immune systems, such as stem cell or organ transplant recipients. Participants receive one or more infusions of these cells, which are designed to target and kill infected cells. The study aims to see if this approach can reduce viral levels and control infections when standard drugs have failed or cannot be used.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
pathogen-specific cytotoxic T lymphocytes (CTLs)
What this could lead to
If it works, this approach could offer a new way to control serious infections in people with weak immune systems, especially when standard drugs fail.
What could go wrong
This is an early-phase trial, so the treatment may not work or could cause side effects like infusion reactions or graft-versus-host-like symptoms.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Shenzhen Geno-immune Medical Institute

    RECRUITING

    Shenzhen, Guangdong, 518000, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.